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Hospital de Órbigo, Spain

Zucchella C.,Neurorehabilitation Unit | Zucchella C.,University of Pavia | Capone A.,Neurorehabilitation Unit | Codella V.,Neurorehabilitation Unit | And 7 more authors.
Functional Neurology | Year: 2014

Cognitive impairment is a frequent complication of stroke. The aim of this study was to evaluate the effectiveness of cognitive training performed early after stroke. Ninety-two patients were randomly assigned to either the study group (SG) or the control group (CG). Cognitive rehabilitation consisted of 16 individual one-hour sessions in which patients performed therapistguided computer exercises. The patients in the CG performed a sham intervention. After four weeks all the patients were re-evaluated. In the SG, significant improvements (p<0.05) were detected in all neuropsychological measures at the post-training evaluation, while the CG showed mild (not statistically significant) improvements on cognitive tests. Between-group analysis revealed statistically significant differences in the domains of memory and visual attention. Cognitive training performed early after stroke seems to be a viable option for improving cognitive outcome in stroke survivors. Further studies should assess whether this may favor their reintegration into everyday life. © 2014, CIC Edizioni Internazionali s.r.l. All rights reserved. Source

Laborde C.M.,Laboratory of Vascular Pathophysiology | Mourino-Alvarez L.,Laboratory of Vascular Pathophysiology | Akerstrom F.,Laboratory of Vascular Pathophysiology | Padial L.R.,Laboratory of Vascular Pathophysiology | And 4 more authors.
Expert Review of Proteomics | Year: 2012

Stroke is one of the most common causes of death worldwide and a major cause of acquired disability in adults. Despite advances in research during the last decade, prevention and treatment strategies still suffer from significant limitations, and therefore new theoretical and technical approaches are required. Technological advances in the proteomic and metabolomic areas, during recent years, have permitted a more effective search for novel biomarkers and therapeutic targets that may allow for effective risk stratification and early diagnosis with subsequent rapid treatment. This review provides a comprehensive overview of the latest candidate proteins and metabolites proposed as new potential biomarkers in stroke. © 2012 Expert Reviews Ltd. Source

Akerstrom F.,Hospital Virgen de la Salud | Akerstrom F.,Laboratory of Vascular Pathophysiology | Barderas M.G.,Laboratory of Vascular Pathophysiology | Rodriguez-Padial L.,Hospital Virgen de la Salud | Rodriguez-Padial L.,Laboratory of Vascular Pathophysiology
Expert Review of Cardiovascular Therapy | Year: 2013

Aortic stenosis is the most prevalent valve pathology and calcific aortic valve disease (CAVD) is its most frequent etiology in developed countries. There is extensive evidence that CAVD represents an active disease process similar to that of atherosclerosis with similar classical cardiovascular risk factors and pathological mechanisms. Given that in the vast majority of situations the only treatment available is valve replacement there is a need to develop pharmacological therapies that retard the disease progression. Lipid-lowering therapies have been the focus of research, however, so far with negative results. Future studies, including animal models, shall provide an opportunity to further evaluate the disease mechanisms of CAVD and to discover potential disease biomarkers and pharmacological interventions that can reduce the need for valve replacement. © 2013 2013 Expert Reviews Ltd. Source

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