Santo André, Brazil
Santo André, Brazil

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Monteiro C.B.M.,University of Sao Paulo | Savelsbergh G.J.P.,VU University Amsterdam | Smorenburg A.R.P.,Burke Cornell Medical Research Institute | Graciani Z.,University of Sao Paulo | And 4 more authors.
Neuropsychiatric Disease and Treatment | Year: 2014

We aimed to evaluate the functional abilities of persons with Rett syndrome (RTT) in stages III and IV. The group consisted of 60 females who had been diagnosed with RTT: 38 in stage III, mean age (years) of 9.14, with a standard deviation of 5.84 (minimum 2.2/maximum 26.4); and 22 in stage IV, mean age of 12.45, with a standard deviation of 6.17 (minimum 5.3/maximum 26.9). The evaluation was made using the Pediatric Evaluation of Disability Inventory, which has 197 items in the areas of self-care, mobility, and social function. The results showed that in the area of self-care, stage III and stage IV RTT persons had a level of 24.12 and 18.36 (P=0.002), respectively. In the area of mobility, stage III had 37.22 and stage IV had 14.64 (P<0.001), while in the area of social function, stage III had 17.72 and stage IV had 12.14 (P=0.016). In conclusion, although persons with stage III RTT have better functional abilities when compared with stage IV, the areas of mobility, self-care, and social function are quite affected, which shows a great functional dependency and need for help in basic activities of daily life. © 2014 Monteiro et al.


Vinegoni C.,Harvard University | Siegel C.,Boston Medical Center | Mlynarchik A.,Brigham and Women's Hospital | Sena B.F.,Harvard University | And 3 more authors.
Frontiers of Gastrointestinal Research | Year: 2013

Intraoperative fluorescence optical imaging of the biliary ducts has been recently shown to be an effective and economically viable imaging methodology for the prevention of biliary injury. While the exploitation of fluorescence imaging during biliary surgeries may still be relatively new, recent efforts have been made toward the development of novel near-infrared (NIR) optical imaging contrast agents with the goal to reduce unwanted intraoperative occurrences. The focus of this chapter is centered on the exploration of novel types of biliary-excreted contrast agents aimed at improving the current state of fluorescence cholangiography. Copyright © 2013 S. Karger AG, Basel.


Demarzo M.M.P.,Federal University of São Paulo | De Oliveira R.M.J.,Federal University of São Paulo | Silva D.F.A.,Federal University of São Paulo | Lessa-Moreno I.,Federal University of São Paulo | And 3 more authors.
Actas Espanolas de Psiquiatria | Year: 2015

The present case study reports the experience of offering a mindfulness-based program to a high performance male Brazilian athlete, 26 years old, with a history of diminished performance following repeated injuries, and severe sleep disturbance. The intervention consisted in an adaptation of the Mindfulness Based Stress Reduction (MBSR) program, created by Jon Kabat-Zinn. The athlete was followed during 23 weeks, with collection of physiological (heart rate variability - HRV) and psychological data (perceived stress, trace and state anxiety, and mindfulness), added to quality of life and sleep assessments. At the end of the program, an in-depth interview was conducted to identify qualitative aspects of his experience with the program (expectations, perceived results and difficulties). The analysis of quantitative and qualitative data suggests that the athlete has shown improvements in physiological and psychological parameters, even while facing several setbacks during the development of the mindfulness program. We can conclude that the implementation of a mindfulness programs addressing high performance athletes may be feasible, with great potential benefits for this type of public, especially for managing physical and psychological demands related to the particularities of the life of a professional athlete. To increase the feasibility of using this type of intervention in highperformance athletes, adapting programs to specific routines and demands (daily agenda and seasonal training and competitions; and potential missed sessions due to injury, commitments with sponsors, etc.) is recommended. It also seems important to maintain the monitoring of athletes for longer periods, to ensure learning and incorporating techniques into the routine of life and training as well as providing integration of other team members when necessary, for instance, in case of the diagnosis of sleep disorders, common in this type of audience.


Torriani-Pasin C.,University of Sao Paulo | Bonuzzi G.M.,University of Sao Paulo | Soares M.A.,University of Sao Paulo | Antunes G.L.,University of Sao Paulo | And 7 more authors.
International Archives of Medicine | Year: 2013

Background: The time synchronization is a very important ability for the acquisition and performance of motor skills that generate the need to adapt the actions of body segments to external events of the environment that are changing their position in space. Down Syndrome (DS) individuals may present some deficits to perform tasks with synchronization demand. We aimed to investigate the performance of individuals with DS in a simple Coincident Timing task. Method. 32 individuals were divided into 2 groups: the Down syndrome group (DSG) comprised of 16 individuals with average age of 20 (+/- 5 years old), and a control group (CG) comprised of 16 individuals of the same age. All individuals performed the Simple Timing (ST) task and their performance was measured in milliseconds. The study was conducted in a single phase with the execution of 20 consecutive trials for each participant. Results: There was a significant difference in the intergroup analysis for the accuracy adjustment - Absolute Error (Z = 3.656, p = 0.001); and for the performance consistence - Variable Error (Z = 2.939, p = 0.003). Conclusion: DS individuals have more difficulty in integrating the motor action to an external stimulus and they also present more inconsistence in performance. Both groups presented the same tendency to delay their motor responses. © 2013 Torriani-Pasin et al.; licensee BioMed Central Ltd.


Contesini N.,Uniasselvi FAMEBLU | Adami F.,Laboratory of Scientific Writing | Adami F.,Campus Universitario Reitor Joao David Ferreira Lima | Blake M.D.-T.,Laboratory of Scientific Writing | And 10 more authors.
International Archives of Medicine | Year: 2013

Background: The aim of this study was to identify dietary strategies for physically active individuals with muscle dysmorphia based on a systematic literature review. Method. References were included if the study population consisted of adults over 18 years old who were physically active in fitness centers. We identified reports through an electronic search ofScielo, Lilacs and Medline using the following keywords: muscle dysmorphia, vigorexia, distorted body image, and exercise. We found eight articles in Scielo, 17 in Medline and 12 in Lilacs. Among the total number of 37 articles, only 17 were eligible for inclusion in this review. Results: The results indicated that the feeding strategies used by physically active individuals with muscle dysmorphia did not include planning or the supervision of a nutritionist. Diet included high protein and low fat foods and the ingestion of dietary and ergogenic supplements to reduce weight. Conclusion: Physically active subjects with muscle dysmorphia could benefit from the help of nutritional professionals to evaluate energy estimation, guide the diet and its distribution in macronutrient and consider the principle of nutrition to functional recovery of the digestive process, promote liver detoxification, balance and guide to organic adequate intake of supplemental nutrients and other substances. © 2013 Contesini et al.; licensee BioMed Central Ltd.


Fujimori M.,University of Sao Paulo | Franca E.L.,Federal University of Mato Grosso | Fiorin V.,Laboratory of Scientific Writing | Morais T.C.,University of Sao Paulo | And 3 more authors.
BMC Pregnancy and Childbirth | Year: 2015

Background: Obesity in pregnancy is associated with systemic inflammation, immunological changes and adverse maternal-fetal outcomes. Information on the association between maternal obesity and breast milk composition is scarce. This study describes changes and relationships between biochemical and immunological parameters of colostrum and serum of overweight and obese women. Methods: Colostrum and blood samples were collected from 25 normal weight, 24 overweight and 19 obese women for determination of glucose, total protein, triglycerides, cholesterol, immunoglobulins, complement proteins (C3 and C4), fat and calorie content and C-reactive protein (CRP). Results: Glucose was higher in colostrum of obese women (p = .002). In normal weight and obese women, total protein content was higher in colostrum than in serum (p = .001). Serum triglycerides (p = .008) and cholesterol (p = .010) concentrations were significantly higher in overweight and obese women than in their normal weight counterparts, but in colostrum their concentrations were similar across the three groups. Secretory IgA (sIgA) in colostrum and IgA in serum concentrations were significantly higher (p = .001) in overweight and obese mothers, whereas IgG and IgM concentrations did not vary among the groups (p = .825). Serum C3 (p = .001) and C4 (p = .040) concentrations were higher in obese women. No differences in colostrum complement proteins were detected among the groups. Calorie content (p = .003) and fat (p = .005) concentrations in colostrum and serum CRP (p = .002) were higher in obese women. Conclusions: The results corroborate the hypothesis that colostrum of overweight and obese women undergoes biochemical and immunological changes that affect its composition, namely increasing glucose concentrations, calorie content, fat and sIgA concentrations. © 2015 Fujimori et al.


Moreno I.L.,Federal University of São Paulo | Moreno I.L.,Paulista University | Pastre C.M.,Paulista University | Ferreira C.,Federal University of São Paulo | And 3 more authors.
Journal of the International Society of Sports Nutrition | Year: 2013

Background: With prolonged physical activity, it is important to maintain adequate fluid balance. The impact of consuming isotonic drinks during and after exercise on the autonomic regulation of cardiac function is unclear. This study aimed to analyze the effects of consuming an isotonic drink on heart rate variability (HRV) during and after prolonged exercise.Methods: Thirty-one young males (21.55 ± 1.89 yr) performed three different protocols (48 h interval between each stage): I) maximal exercise test to determine the load for the protocols; II) Control protocol (CP) and; III). Experimental protocol (EP). The protocols consisted of 10 min at rest with the subject in the supine position, 90 min of treadmill exercise (60% of VO2 peak) and 60 min of rest placed in the dorsal decubitus position. No rehydration beverage consumption was allowed during CP. During EP, however, the subjects were given an isotonic solution (Gatorade, Brazil) containing carbohydrate (30 g), sodium (225 mg), chloride (210 mg) and potassium (60 mg) per 500 ml of the drink. For analysis of HRV data, time and frequency domain indices were investigated. HRV was recorded at rest (5-10 min), during exercise (25-30 min, 55-60 min and 85-90 min) and post-exercise (5-10 min, 15-20 min, 25-30 min, 40-45 min and 55-60 min).Results: Regardless of hydration, alterations in the SNS and PSNS were observed, revealing an increase in the former and a decrease in the latter. Hydrating with isotonic solution during recovery induced significant changes in cardiac autonomic modulation, promoting faster recovery of linear HRV indices.Conclusion: Hydration with isotonic solution did not significantly influence HRV during exercise; however, after exercise it promoted faster recovery of linear indices. © 2013 Moreno et al.; licensee BioMed Central Ltd.


Moreno I.L.,Federal University of São Paulo | Vanderlei L.C.M.,Paulista University | Pastre C.M.,Paulista University | Vanderlei F.M.,Federal University of São Paulo | And 2 more authors.
International Archives of Medicine | Year: 2013

Background: In prolonged exercise, the state of hypohydration due to sweating raises physiological stress and induces a drop in sports performance. However, the impact of water intake in cardiorespiratory parameters when administered during and after physical activity has not been well studied. This study aimed to analyze the effects of water intake in heart rate (HR), systolic blood pressure (SBP), diastolic blood pressure (DBP), partial oxygen saturation (SpO§ssub§2§esub§) and respiratory rate during and after prolonged exercise. Methods. Thirty-one young males (21.55 ± 1.89 yr) performed three different protocols (48 h interval between each stage): I) maximal exercise test to determine the load for the protocols; II) Control protocol (CP) and; III) Experimental protocol (EP). The protocols consisted of 10 min at rest with the subject in the supine position, 90 min of treadmill exercise (60% of VO§ssub§2§esub§ peak) and 60 min of rest placed in the dorsal decubitus position. No rehydration beverage consumption was allowed during CP. During EP, however, the subjects were given water (Vittalev, Spaipa, Brazil). The parameters HR, SBP, DBP, SpO§ssub§2§ esub§ and respiratory rate were measured at the end of the rest, in 30, 60 and 90 minutes of the activity, except the respiratory rate parameter, and at 1, 3, 5, 7, 10, 20, 30, 40, 50 and 60 minute post- exercise. Results: The hydration protocol provided minimal changes in SBP and DBP and a smaller increase in HR and did not significantly affect SpO§ssub§2§ esub§ during exercise and better HR recovery, faster return of SBP and DBP and a better performance for SpO§ssub§2§esub§ and respiratory rate post-exercise. Conclusion: Hydration with water influenced the behavior of cardiorespiratory parameters in healthy young subjects. © 2013 Moreno et al.; licensee BioMed Central Ltd.


PubMed | Laboratory of Scientific Writing, Federal University of Mato Grosso and University of Sao Paulo
Type: | Journal: BMC pregnancy and childbirth | Year: 2015

Obesity in pregnancy is associated with systemic inflammation, immunological changes and adverse maternal-fetal outcomes. Information on the association between maternal obesity and breast milk composition is scarce. This study describes changes and relationships between biochemical and immunological parameters of colostrum and serum of overweight and obese women.Colostrum and blood samples were collected from 25 normal weight, 24 overweight and 19 obese women for determination of glucose, total protein, triglycerides, cholesterol, immunoglobulins, complement proteins (C3 and C4), fat and calorie content and C-reactive protein (CRP).Glucose was higher in colostrum of obese women (p =.002). In normal weight and obese women, total protein content was higher in colostrum than in serum (p =.001). Serum triglycerides (p =.008) and cholesterol (p =.010) concentrations were significantly higher in overweight and obese women than in their normal weight counterparts, but in colostrum their concentrations were similar across the three groups. Secretory IgA (sIgA) in colostrum and IgA in serum concentrations were significantly higher (p =.001) in overweight and obese mothers, whereas IgG and IgM concentrations did not vary among the groups (p =.825). Serum C3 (p =.001) and C4 (p =.040) concentrations were higher in obese women. No differences in colostrum complement proteins were detected among the groups. Calorie content (p =.003) and fat (p =.005) concentrations in colostrum and serum CRP (p =.002) were higher in obese women.The results corroborate the hypothesis that colostrum of overweight and obese women undergoes biochemical and immunological changes that affect its composition, namely increasing glucose concentrations, calorie content, fat and sIgA concentrations.

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