Laboratory of Quality & Safety Risk Assessment for Agro products on Storage and Preservation Chongqing

Quality & Safety Risk Assessment for Agro products on Storage and, China

Laboratory of Quality & Safety Risk Assessment for Agro products on Storage and Preservation Chongqing

Quality & Safety Risk Assessment for Agro products on Storage and, China
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Ding Y.,Southwest University | Ding Y.,Laboratory of Quality & Safety Risk Assessment for Agro products on Storage and Preservation Chongqing | Pu L.,Southwest University | Pu L.,Laboratory of Quality & Safety Risk Assessment for Agro products on Storage and Preservation Chongqing | And 2 more authors.
Journal of Functional Foods | Year: 2017

In this study, we used adlay and barley bran as substrates to prepare Monascus-fermented grains and discussed the optimum conditions for monacolin K production. Box–Behnken design results showed that the predicted maximum monacolin K yield (112.649 mg/kg) was close to the experimental value (110.556 ± 17.17 mg/kg) under optimum conditions (fermentation temperature, 28.76 °C; inoculation amount, 7.81%; and solid substrate concentration, 38.75 g/250 mL). We investigated the hypolipidemic effects of the lipid-lowering granulated tea preparation from Monascus-fermented grains (adlay and barley bran) mixed with lotus leaves enriched with bioactive mevinolins (natural statins) in hyperlipidemic rats for 7 weeks. Results showed that the lipid-lowering granulated tea decreased the body weight gain, serum total cholesterol (TC) and triglyceride (TG) levels, atherogenic index, and liver TC and TG levels. The preparation also increased the cecal weight, surface area, and content weight, as well as the concentrations of butyric acid. Furthermore, the preparation affected the intestinal microbiota and the liver. © 2017 Elsevier Ltd


Ren T.,Southwest University | Ren T.,Laboratory of Quality & Safety Risk Assessment for Agro products on Storage and Preservation Chongqing | Zhu Y.,Chongqing University | Xia X.,Southwest University | And 4 more authors.
Journal of Molecular Endocrinology | Year: 2017

This study aimed to evaluate the protein metabolism effect of Zanthoxylum alkylamides and to explore the potential mechanism in streptozotocin (STZ)-induced diabetic rats. Diabetic rats were orally treated with 2, 4 and 8 mg per kg bw of alkylamides daily for 28 days. Alkylamides decreased the relative weight of the liver and food intake, significantly increased the relative skeletal muscle weight and significantly decreased the blood urea nitrogen levels. Insulin, insulin-like growth factor 1, total protein (TP) and albumin (ALB), globular proteins and ALB proteins/globulin protein levels in serum significantly increased. TP, RNA content and RNA/DNA ratio significantly increased in the skeletal muscle of diabetic rats. Real-time quantitative polymerase chain reaction results indicated that alkylamides significantly increased the mRNA expression of insulin receptor (InR), IGF1 and insulin-like growth factor 1 receptor (IGF1R) in the liver and skeletal muscle. Moreover, the mRNA and protein expression levels of PI3K, PKB and mTOR significantly increased, whereas those of atrogin-1, muscle ring finger 1 and FOXO in the skeletal muscle significantly decreased. Alkylamides may advance protein synthesis by the PI3K/PKB/mTOR signalling pathway and attenuate the catabolism of protein through the ubiquitin–proteasome pathway. Therefore, it was possible that alkylamides ameliorate protein metabolism disorders in diabetic rats by activating the mTOR pathway. © 2017 The authors.


Zhang J.,Southwest University | Xie J.,Southwest University | Zhou Y.,Southwest University | Deng L.,Southwest University | And 3 more authors.
Biological Control | Year: 2017

The use of antagonistic yeasts to control postharvest pathogens is a promising alternative to fungicides. The effect of the yeast antagonists Pichia membranaefaciens and Kloeckera apiculata for controlling brown rot of plums in postharvest and the antifungal activity of the two yeast strains in in vitro conditions against Monilinia fructicola were investigated. In in vivo trials, both P. membranaefaciens and K. apiculata showed a significant reduction of rot incidence produced by M. fructicola by 76.0% and 65.8%, respectively. In in vitro trials, spore germination and mycelial growth of M. fructicola were markedly inhibited by P. membranaefaciens and K. apiculata. In addition, the two antagonistic yeasts, especially K. apiculata, had attachment to the hyphae of M. fructicola. Moreover, P. membranaefaciens and K. apiculata secreted hydrolytic enzymes, such as chitinase (CHI) and β-1, 3-glucanase (GLU). According to these results, P. membranaefaciens and K. apiculata might have the ability to parasitize M. fructicola. The volatile organic compounds (VOCs) produced by P. membranaefaciens and K. apiculata had a significant inhibitory effect on M. fructicola in vitro and in vivo. VOCs in a simultaneous incubation (SI) trial showed the best inhibition. © 2017 Elsevier Inc.

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