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Hamden K.,University of Sfax | Carreau S.,Caen University Hospital Center | Aouidet A.,UR | El-Fazaa S.,Laboratory of Physiology of Aggressions | And 2 more authors.
Archives of Physiology and Biochemistry | Year: 2010

The current study showed that the daily oral treatment of fenugreek steroids, designated F(steroids), to diabetic rats during 30 days demonstrated a significant (p<0.05) decrease of blood glucose level and a considerable increase of the area of insulin-immunoreactive β-cells in diabetic rats. Interestingly, this study showed that F(steroids) potentially unregulated the key steroidogenesis enzymes such as 3-hydroxy-3-methyl-glutaryl-CoA reductase (HMG-CoA reductase), malic enzyme, 3β-hydroxysteroid dehydrogenase (3β-HSD) and glucose-6-phosphate dehydrogenase (G6P-DH) activities as cholesterol rate in testis, which considerably enhanced testosterone and estradiol levels in the plasma of surviving diabetic rats. More interestingly, F(steroids) obviously prevented the alteration of the key carbohydrate enzymes such as hexokinase and pyruvate kinase activities as well as testicular glycogen and seminal fructose contents in surviving diabetic rats. Furthermore, F(steroids) administration to surviving diabetic rats significantly decreased the sperm shape abnormality and improved the sperm count. Above all, the potential protective action of reproductive systems was approved by the histological study of testis and epididymis. © 2010 Informa UK Ltd. Source

Hamden K.,University of Sfax | Allouche N.,University of Sfax | El-Fazaa S.,Laboratory of Physiology of Aggressions | Gharbi N.,Laboratory of Physiology of Aggressions | And 3 more authors.
Food Science and Biotechnology | Year: 2010

This study was established that after 3 months storage, olive mill waste (OMW) was enriched with hydroxytyrosol (HT) (2,652 mg/L) and contained only phenolic monomers. It also showed that HT supplementation to surviving diabetic rats decreases considerably intestinal maltase, lactase, sucrose, and lipase activities by 49, 31, 42, and 40%, respectively. In addition, HT enhanced the superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPX) activities by 330, 170, and 301%, respectively and reduced gluthation (GSH) level by 79% in pancreas compared to diabetic rats. Moreover, a significant decrease in the thiobarbituric acid reactive substances (TBARs) level and lactate dehydrogenase (LDH) activity in diabetic rats pancreas by 34 and 49% respectively after administration of HT. In addition, HT improved plasma triglyceride and cholesterol levels in diabetic rats by lowering low density lipoprotein (LDL)- cholesterol and triglycerides (TG) by 27 and 53%, respectively and increasing high density lipoprotein (HDL)-cholesterol content by 72%. These properties of HT are interesting regarding its use as therapeutic agent in biotechnological applications, especially in developing anti-diabetic and hypocholesterolemic drugs. © KoSFoST and Springer 2010. Source

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