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Pajares M.,Institute Investigaciones Biomedicas Alberto Sols CSIC UAM | Pajares M.,Institute Investigacion Sanitaria La Paz IdiPAZ | Pajares M.,CIBER ISCIII | Jimenez-Moreno N.,Institute Investigaciones Biomedicas Alberto Sols CSIC UAM | And 13 more authors.
Redox Biology | Year: 2015

Intracellular proteolysis is critical to maintain timely degradation of altered proteins including oxidized proteins. This review attempts to summarize the most relevant findings about oxidant protein modification, as well as the impact of reactive oxygen species on the proteolytic systems that regulate cell response to an oxidant environment: the ubiquitin-proteasome system (UPS), autophagy and the unfolded protein response (UPR). In the presence of an oxidant environment, these systems are critical to ensure proteostasis and cell survival. An example of altered degradation of oxidized proteins in pathology is provided for neurodegenerative diseases. Future work will determine if protein oxidation is a valid target to combat proteinopathies. © 2015 The Authors.

Jacob V.,Laboratory of Oxidative Stress Research | Jacob V.,Tel-Hai Academic College | Hagai T.,Laboratory of Oxidative Stress Research | Hagai T.,Tel-Hai Academic College | And 2 more authors.
Current Organic Chemistry | Year: 2011

Flavonoids are secondary metabolites produced in plants that have diverse biological activities. The present review summarizesinformation gathered mostly in the last six years on the flavonoids' structure-activity relationships, specifically with respect to: A)phytoestrogenic activity-flavonoids' potential to replace estrogen during the menopausal period and especially fascinating, the possibilityof finding flavonoids selective for estrogen receptor β B) as antioxidants-their potential to treat oxidative stress-associated diseases; C)as whitening agents-potentially active via their ability to inhibit the enzyme tyrosinase; D) flavonoids that are active due to their interactionwith proteins (enzymes, receptors, transporters and transcription factors), an area which we believe will attract much more attentionin the near future, in helping to understand the role of flavonoids and their mechanism of action in the treatment of human diseases. Thisreview covers data collected from experiments performed using flavonoids with known structure rather than crude extracts, and in thefirst two sections (A and B), the focus is on results obtained from in-vivo experiments, where available. © 2011 Bentham Science Publishers Ltd.

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