Laboratory of Organic Synthesis

Socorro, NM, United States

Laboratory of Organic Synthesis

Socorro, NM, United States

Time filter

Source Type

Stathakis C.I.,Laboratory of Organic Synthesis | Gkizis P.L.,Laboratory of Organic Synthesis | Zografos A.L.,Aristotle University of Thessaloniki
Natural Product Reports | Year: 2016

Covering: up to 2015 Sesquiterpenoids are consistently attracting the interest of the scientific community due to their promising clinical profile as therapeutic agents. Cycloisomerization of enynes and dienes is a powerful tool in the hands of organic chemists to access them. In the last 20 years the field has witnessed remarkable advances, especially by revealing the capability of platinum and gold complexes to initiate such reactions. Nowadays, cycloisomerizations continue to enrich our knowledge with atom-economical routes and impressive cascades to reach more complex molecules. The current review covers the basic mechanistic aspects of metal catalysis in cycloisomerization reactions and their progress to the synthesis of selected complex sesquiterpenoids. © 2016 The Royal Society of Chemistry.


Janser R.F.J.,Laboratory of Organic Synthesis | Meka R.K.,Laboratory of Organic Synthesis | Bryant Z.E.,Laboratory of Organic Synthesis | Adogla E.A.,Laboratory of Organic Synthesis | And 8 more authors.
Bioorganic and Medicinal Chemistry Letters | Year: 2010

A series of ethacrynic acid analogues, lacking the α,β-unsaturated carbonyl unit, was synthesized and subsequently evaluated for their ability to inhibit the migration of human breast cancer cells, MCF-7/AZ. Several of the analogues were already active in the low micromolar range, whereas ethacrynic acid itself shows no potential to inhibit the migration of these cancer cells. Preliminary studies show that the presence of one or more methoxy groups at the phenyl ring of ethacrynic acid is important in order for the ethacrynic acid analogues to demonstrate an inhibitory effect on the migration. © 2010 Elsevier Ltd. All rights reserved.


Mokle S.S.,Laboratory of Organic Synthesis | Khansole S.V.,Laboratory of Organic Synthesis | Patil R.B.,Yeshwant Mahavidyalaya | Vibhute Y.B.,Laboratory of Organic Synthesis
International Journal of Pharma and Bio Sciences | Year: 2010

New chalcones (3a-h) were synthesized from 2-chloro-8-methoxy-quinoline-3-carbaldehyde (2) and halohydroxysubstitued acetophenones (1a-h) via Claisen-Schmidt condensation. Further new flavones (4a-h) were synthesized by oxidative cyclisation of chalcones (3a-h) using microwave as well as by conventional method. The structures of synthetic compounds were established on the basis of analytical and spectral data. These compounds were screened for their antibacterial activity.


Vibhute A.,Laboratory of Organic Synthesis | Mokle S.,Laboratory of Organic Synthesis | Karamunge K.,Laboratory of Organic Synthesis | Gurav V.,Laboratory of Organic Synthesis | Vibhute Y.,Laboratory of Organic Synthesis
Chinese Chemical Letters | Year: 2010

Green, mild and efficient iodination of hydroxylated aromatic aldehydes and ketones using iodine and iodic acid in the solid-state by grinding under solvent-free conditions at room temperature. This method provides several advantages such as environmentally friendly, short reaction times, high yields, non-hazardous and simple work-up procedure. © 2010 Yeshwant Vibhute. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.


Zangade S.,Laboratory of Organic Synthesis | Shinde A.,Laboratory of Organic Synthesis | Sundge S.,Laboratory of Organic Synthesis | Vibhute Y.,Laboratory of Organic Synthesis
Analele Universitatii Bucuresti Chimie | Year: 2011

A simple, rapid and highly efficient synthesis of 1,5-benzothiazepines by condensation of 2'-hydroxychalcones and o-aminophenol using 2-methoxyethanol as an alternative and environmentally benign solvent under microwave irradiation. The clean reaction conditions, shorter reaction time and high yields and purity of product are notable advantages of method. © 2011 Analele UniversitǎŃii din Bucuresti.


Shetye A.,Laboratory of Organic Synthesis | Tamboli M.,Laboratory of Organic Synthesis | Mokle S.,Laboratory of Organic Synthesis | Zangade S.,Laboratory of Organic Synthesis
Der Pharma Chemica | Year: 2011

Halogenosubstituted vanillins were prepared by halogenations. Halogenosubstituted vanillins on Knoevenagel condensation with malonic acid to form halogenosubstituted cinnamic acids by using conventional method as well as microwave irradiation technique. All halogenosubstituted cinnamic acids were screened for antibacterial activity. All newly synthesized halogenosubstituted cinnamic acids showed antibacterial activity to a remarkable extent.


Chavan S.B.,Laboratory of Organic Synthesis | Zangade S.B.,Laboratory of Organic Synthesis | Archana,Laboratory of Organic Synthesis | Vibhute Y.,Laboratory of Organic Synthesis | Vibhute Y.B.,Laboratory of Organic Synthesis
Research Journal of Pharmaceutical, Biological and Chemical Sciences | Year: 2012

New halogeno Schiff bases and formazans were synthesized and evaluated for antimicrobial activity. Newly synthesized Schiff bases and formazans showed potent activity.


Moklei S.S.,Laboratory of Organic Synthesis | Vibhute A.Y.,Laboratory of Organic Synthesis | Khansole S.V.,Laboratory of Organic Synthesis | Zangade S.B.,Laboratory of Organic Synthesis | Vibhute Y.B.,Laboratory of Organic Synthesis
Research Journal of Pharmaceutical, Biological and Chemical Sciences | Year: 2010

In present investigation, a series of 2-pyrazolines (2a-P) were prepared by cyclization of hydrazine hydrate/phenyl hydrazine with α, (β-unsaturated ketone (chalcones) using triethanolamine solvent within 15-20 min. The newly synthesized 2-pyrazolines were characterized on the basis of elemental analysis and spectroscopic data. All newly synthesized compounds were evaluated for their antibacterial activity. Most of the compounds showed potent activity.


Zangade S.B.,Laboratory of Organic Synthesis | Mokle S.S.,Laboratory of Organic Synthesis | Shinde A.T.,Laboratory of Organic Synthesis | Vibhute Y.B.,Laboratory of Organic Synthesis
Green Chemistry Letters and Reviews | Year: 2013

A simple, rapid, efficient, and environmentally benign procedure for synthesis of 2-pyrazoline derivatives has been achieved by reacting 2′-hydroxychalcones with hydrazine hydrate under solvent-free grinding technique. The short reaction time, cleaner reaction, easy workup, higher yields, and mild reaction conditions make this protocol practical and economically attractive in comparison with the classical reaction. © 2013 Copyright Sainath B. Zangade, Shyam S. Mokle, Avinash T. Shinde and Yeshwant B. Vibhute.

Loading Laboratory of Organic Synthesis collaborators
Loading Laboratory of Organic Synthesis collaborators