Laboratory of Organic Reaction

Sapporo, Japan

Laboratory of Organic Reaction

Sapporo, Japan
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Yamauchi Y.,Laboratory of Organic Reaction | Hara S.,Laboratory of Organic Reaction | Senboku H.,Laboratory of Organic Reaction
Tetrahedron | Year: 2010

Electrochemical carboxylation of (1-bromo-2,2,2-trifluoroethyl)arenes resulted in an efficient fixation of carbon dioxide to give the corresponding 2-aryl-3,3,3-trifluoropropanoic acids in good yields, and the present reactions were successfully applied to the synthesis of β,β,β-trifluorinated non-steroidal anti-inflammatory drugs (NSAIDs). © 2009 Elsevier Ltd. All rights reserved.


Senboku H.,Laboratory of Organic Reaction | Michinishi J.-Y.,Laboratory of Organic Reaction | Hara S.,Laboratory of Organic Reaction
Synlett | Year: 2011

Facile synthesis of 2,3-dihydrobenzofuran-3-ylacetic acids and related analogues was successfully carried out by a novel electrochemical aryl radical generation and its 5-exo cyclization followed by a carboxylation sequence of 2-allyloxybromobenzenes by using methyl 4-tert-butylbenzoate as an electron-transfer mediator. © Georg Thieme Verlag Stuttgart • New York.


Senboku H.,Laboratory of Organic Reaction | Nakahara K.,Laboratory of Organic Reaction | Fukuhara T.,Laboratory of Organic Reaction | Hara S.,Laboratory of Organic Reaction
Tetrahedron Letters | Year: 2010

Hg cathode-free electrochemical detosylation of N,N-disubstituted p-toluenesulfonamides was successfully carried out by a constant current electrolysis using an undivided cell equipped with a platinum cathode and a magnesium anode in the presence of an arene mediator. The deprotection proceeded efficiently and selectively under neutral and mild conditions with a stoichiometric amount of electricity without the use of an Hg cathode to obtain the corresponding secondary amines in good to excellent yields. © 2009 Elsevier Ltd. All rights reserved.

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