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Wei L.,Laboratory of Nuclear and Radiation Damage | Qisheng J.,Laboratory of Nuclear and Radiation Damage
Cancer Research and Clinic | Year: 2014

Polo-like kinase 1 (Plkl) is a serine/threonine kinase that is widely expressed in eukaryotic cells and a key regulator of the cell mitosis. During different stages of mitosis, the locations of Plkl in cells are different, and can interaction with different substrates, thus it has many biological functions. This article focuses on the functions of Plkl in different mitotic stages. Source


Wei L.,Laboratory of Nuclear and Radiation Damage | Huijie Y.,Laboratory of Nuclear and Radiation Damage | Qisheng J.,Laboratory of Nuclear and Radiation Damage
Cancer Research and Clinic | Year: 2015

The technique of chimeric antigen receptor-engineered T cells (CAR-T) is combined single chain antibody and T-cell activation modification and has specific and durable killing effect on tumors. It had achieved stunning results on clinical trials of B lymphocytic leukemias, B lymphomas and solid tumors. Meanwhile it also had potential risk on the off target effects, cytokine release syndrome, graft versus host disease and so on. This paper briefly reviews the principal of CAR-T cellular mechanism, advantages and clinical applications. Source


Xiujun S.,Laboratory of Nuclear and Radiation Damage | Fengsheng L.,Laboratory of Nuclear and Radiation Damage | Qisheng J.,Laboratory of Nuclear and Radiation Damage
Cancer Research and Clinic | Year: 2014

miRNA is a kind of small, endogenous noncoding RNA which regulates gene expression in post-transcription level and is highly conserved and tissue-specificity. miRNA generally participates the regulation of many complicated vital process, such as cell growth, development and also plays an important role in the pathogenesis of many kinds of tumors. miR-34b is a newly discovered miRNA, which is regulated by p53, promoter methylation and so on. miR-34b can regulate cellular proliferation and apoptosis, and also involves in the generation and regulation of tumor, which suggests wide application prospect in therapy and prognosis of tumor. This review will focus on the progress of miR-34b and its relationship with tumor. Source

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