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Thessaloníki, Greece

Lithari C.,Laboratory of Medical Informatics | Klados M.A.,Laboratory of Medical Informatics | Pappas C.,Laboratory of Medical Informatics | Albani M.,Laboratory of Physiology | And 4 more authors.
PLoS ONE | Year: 2012

Acute alcohol intake is known to enhance inhibition through facilitation of GABAA receptors, which are present in 40% of the synapses all over the brain. Evidence suggests that enhanced GABAergic transmission leads to increased large-scale brain connectivity. Our hypothesis is that acute alcohol intake would increase the functional connectivity of the human brain resting-state network (RSN). To test our hypothesis, electroencephalographic (EEG) measurements were recorded from healthy social drinkers at rest, during eyes-open and eyes-closed sessions, after administering to them an alcoholic beverage or placebo respectively. Salivary alcohol and cortisol served to measure the inebriation and stress levels. By calculating Magnitude Square Coherence (MSC) on standardized Low Resolution Electromagnetic Tomography (sLORETA) solutions, we formed cortical networks over several frequency bands, which were then analyzed in the context of functional connectivity and graph theory. MSC was increased (p<0.05, corrected with False Discovery Rate, FDR corrected) in alpha, beta (eyes-open) and theta bands (eyes-closed) following acute alcohol intake. Graph parameters were accordingly altered in these bands quantifying the effect of alcohol on the structure of brain networks; global efficiency and density were higher and path length was lower during alcohol (vs. placebo, p<0.05). Salivary alcohol concentration was positively correlated with the density of the network in beta band. The degree of specific nodes was elevated following alcohol (vs. placebo). Our findings support the hypothesis that short-term inebriation considerably increases large-scale connectivity in the RSN. The increased baseline functional connectivity can -at least partially- be attributed to the alcohol-induced disruption of the delicate balance between inhibitory and excitatory neurotransmission in favor of inhibitory influences. Thus, it is suggested that short-term inebriation is associated, as expected, to increased GABA transmission and functional connectivity, while long-term alcohol consumption may be linked to exactly the opposite effect. © 2012 Lithari et al. Source


Elfatoiki F.Z.,Ibn Rochd UHC of Casablanca | Elfatoiki F.Z.,Laboratory of Immunology | El Azhari M.,Pasteur Institute | El Kettani A.,Laboratory of Medical Informatics | And 6 more authors.
Pan African Medical Journal | Year: 2016

Psoriatic lesions are rarely complicated by recurrent infections. The aim of our study is to determine skin colonisation and nasal carriage of Staphylococcus aureus in patients with psoriasis and in healthy persons. Patients and methods: a comparative study that include 33 patients with psoriasis and 33 healthy persons.Samples were taken from lesional and non lesional psoriatic skin and from healthy skin of control group. For S. aureus nasal carriage, we used sterile cotton tipped swabs. Out of165 samples (66 skin samples and 33 nasal swabs), 26 S. Aureus strains were isolated in 26 persons, 57.69% in the control group and 42.3% in the psoriasisgroup. S. aureus skin colonization was found in one case (3%) inlesional psoriatic skin vs 9 cases (27.3%) in control skin OR=0.08 IC 95% (0.01-0.70) p=0.02 and in 12,1% in non lesional soriatic skin vs 27, 3% in control skin (p =0,13). This colonization was less important in lesional psoriatic skin (3%) than in non lesional psoriatic skin (12.1%) p= 0.20. Nasal screening identified (7/33) 21, 21% S. aureus carriers in psoriasis group and in control group. Our results are in consensus withliterature findings. They have confirmed the importance of antimicrobial peptides in Innateimmunity of human skin. These peptides are normally produced bykeratinocytes in response to inflammatory stimuli such as psoriasis. Their high expression in psoriasis skin reduces the risk of skin infection and skin colonization with S. Aureus. © Fatima Zahra Elfatoiki et al. Source


Komnidis A.,Laboratory of Medical Informatics | Konstantinidis E.,Laboratory of Medical Informatics | Stylianou I.,Aristotle University of Thessaloniki | Klados M.A.,Laboratory of Medical Informatics | And 2 more authors.
IFMBE Proceedings | Year: 2010

Olfactometers are widely used in the study of the chemical senses from a neurophysiological point of view. Although there is a plethora of olfactometer designs, all of them lack of flexibility in modification. In more details they are not able to dynamically increase the number of odors that can be provided simultaneously or they are not capable to use other form of odorous material than the one they've been designed for. In addition to all these the concentration of the stimulus is estimated indirectly through the ratio of the odorized and the odorless air that is delivered to the subject. Taking into account all these, it is understandable that there is an urgent need for an effective olfactometer which will be able to overcome the aforementioned drawbacks of the existing olfactometers. In this scope, the current study comes to introduce a new computer - operated olfactometer. Its novelty lies on the fact that it has a modular architecture with microcontroller units in every module, which can undoubtfully simplify the system's modification. On the other hand it can also estimate directly the Volatile Organic Compounds (VOC) with one sensor for every odor, and one sensor for the overall stimulus. © 2010 International Federation for Medical and Biological Engineering. Source

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