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Dekaken A.,El Okbi Hospital | Gouri A.,Laboratory of Medical Biochemistry | Bentorki A.A.,El Okbi Hospital | Yakhlef A.,Ibn Zohr Hospital
Annales de Biologie Clinique | Year: 2014

Primary hyperparathyroidism is a common endocrine disorder, asymptomatic and diagnosed through a fortuitous hypercalcemia. Browntumors are exceptional but severe hyperparathyroidism bone complications.We report in this paper an original observation of hyperparathyroidism due to a parathyroid adenoma presenting as a brown tumor. A 28 year-old girl admitted for a bone tumor of the knee, the blood test shows hypercalcemia with hyperparathyroidism, bone biopsy revealed giant cell lesions characteristic of brown tumors. Source

Simon F.,Laveran Military Teaching Hospital | Javelle E.,Laveran Military Teaching Hospital | Oliver M.,Laboratory of Medical Biochemistry | Leparc-Goffart I.,Institute for Biomedical Research of the French Army | And 2 more authors.
Current Infectious Disease Reports | Year: 2011

Chikungunya virus (CHIKV) is an alphavirus transmitted by mosquitoes, mostly Aedes aegypti and Aedes albopictus. After half a century of focal outbreaks of acute febrile polyarthralgia in Africa and Asia, the disease unexpectedly spread in the past decade with large outbreaks in Africa and around the Indian Ocean and rare autochthonous transmission in temperate areas. This emergence brought new insights on its pathogenesis, notably the role of the A226V mutation that improved CHIKV fitness in Ae. albopictus and the possible CHIKV persistence in deep tissue sanctuaries for months after infection. Massive outbreaks also revealed new aspects of the acute stage: the high number of symptomatic cases, unexpected complications, mother-to-child transmission, and low lethality in debilitated patients. The follow-up of patients in epidemic areas has identified frequent, long-lasting, rheumatic disorders, including rare inflammatory joint destruction, and common chronic mood changes associated with quality-of-life impairment. Thus, the globalization of CHIKV exposes countries with Aedes mosquitoes both to brutal outbreaks of acute incapacitating episodes and endemic long-lasting disorders. © 2011 The Author(s). Source

D'Hooghe M.,Hospital Sint Jan | Selleslag D.,Hospital Sint Jan | Mortier G.,University of Antwerp | Van Coster R.,Ghent University | And 3 more authors.
European Journal of Paediatric Neurology | Year: 2012

X-linked sideroblastic anemia and ataxia (XLSA-A) is a rare cause of early onset ataxia, which may be overlooked due to the usually mild asymptomatic anemia. The genetic defect has been identified as a mutation in the ABCB7 gene at Xq12-q13. The gene encodes a mitochondrial ATP-binding cassette (ABC) transporter protein involved in iron homeostasis. Until now only three families have been reported, each with a distinct missense mutation in this gene. We describe a fourth family with XLSA-A and a novel mutation in the ABCB7 gene. © 2012 European Paediatric Neurology Society. Published by Elsevier Ltd. All rights reserved. Source

Gomez N.,University of Sfax | Touihri K.,University of Sfax | Matheeussen V.,Laboratory of Medical Biochemistry | Da Costa A.M.,University of Sfax | And 11 more authors.
European Journal of Heart Failure | Year: 2012

Aims Recent studies indicate that brain natriuretic peptide (BNP 1-32) may be truncated into BNP 3-32 by dipeptidyl peptidase IV (DPP4) and that BNP 3-32 has reduced biological activities compared with BNP 1-32. We investigated if DPP4 contributes to the cardiorenal alterations and to the attenuated response to BNP seen in heart failure. Methods and results Haemodynamic and renal assessment was performed in 12 pigs at baseline, 4 weeks after pacing-induced heart failure, and during BNP infusion. They were randomized to either placebo or treatment with a DPP4 inhibitor, sitagliptin. After 4 weeks of pacing, heart rate was reduced compared with baseline in the sitagliptin group (60 ± 2 vs. 95 ± 16 b.p.m., P < 0.01), and an increase in stroke volume was observed in the sitagliptin group compared with placebo (+24 ± 6% vs.-17 ± 7%, P < 0.01). Glomerular filtration rate declined at week 4 compared with baseline in the placebo group (1.3 ± 0.4 vs. 2.3 ± 0.3 mL/kg/min, P < 0.01) but remained preserved in the sitagliptin group [1.8 ± 0.2 vs. 2.0 ± 0.3 mL/kg/min, P = NS (non-significant)]. In the sitagliptin group, BNP infusion improved end-systolic elastance (68 ± 5 vs. 31 ± 4 mmHg/kg/mL, P < 0.05), ventriculararterial coupling, and mechanical efficiency. Compared with controls (n = 6), myocardial gene expression of BNP, interleukin-6, Na +-Ca 2+ exchanger, and calmodulin was up-regulated in the placebo group, but not in the sitagliptin group. Conclusion In pacing-induced heart failure, DPP4 inhibition preserves the glomerular filtration rate, modulates stroke volume and heart rate, and potentiates the positive inotropic effect of exogenous BNP at no energy expense. © 2011 The Author. Source

Gouri A.,Laboratory of Medical Biochemistry | Dekaken A.,El Okbi Hospital | Bentorki A.A.,Laboratory of Medical Biochemistry | Touaref A.,Laboratory of Medical Biochemistry | And 2 more authors.
Clinical Laboratory | Year: 2014

Background: Elevated serum uric acid (SUA) was usually associated with an increased risk of cardiovascular events and mortality in the general population. However, there are few reports concerning the clinical impact and the pathogenic role of uric acid (UA) in hemodialysis (HD) patients. The aim of the study was to investigate the relationship between SUA and various cardiovascular (CV) risk factors in HD patients. Methods: This retrospective, observational cohort study includes 45 HD patients with a mean age of 51.26 ± 15.21 years. The differences of the CV risk factors between the patients according to their SUA levels were investigated. Results: Age, cardiovascular diseases (CVD), increased creatinine, fasting blood glucose (FBG), corrected calcium (cCa), phosphate (P), cCa x P product, and LDL cholesterol levels were associated with lower SUA levels, whereas a higher SUA level was associated with diabetes mellitus (DM), hypertension, and increased triglycerides level (p < 0.01). In multiple regression analysis, history of diabetes (β = 0.360, p < 0.05), reduced corrected serum calcium (cCa) (β = -1.456, p < 0.01), and phosphate (P) levels (β = -1.752, p < 0.01) were predictive of an increased SUA concentration. Conclusions: Despite what has been demonstrated in the general population and DM patients, a lower SUA level in HD patients was associated with higher cardiovascular risk factors and high co-morbidity burden. Moreover, higher SUA concentrations may be cardioprotective in dialysis patients. Source

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