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Changzheng, China

Piao S.-J.,Laboratory of Marine Drugs | Jiao W.-H.,Shanghai JiaoTong University | Yang F.,Shanghai JiaoTong University | Yi Y.-H.,Laboratory of Marine Drugs | And 3 more authors.
Marine Drugs | Year: 2014

Five new sesterterpenoids, compounds 1-5, have been isolated from the sponge Hippospongia lachne off Yongxing Island in the South China Sea. The structures of compounds 1-5 were elucidated through extensive spectroscopic analysis, including HRMS, 1D, and 2D NMR experiments. The stereochemistry, including absolute configurations of these compounds, was determined by spectroscopic, chemical, and computational methods. Compounds 1 and 5 showed moderate protein tyrosine phosphatase 1B (PTP1B) inhibitory activities with IC50 values of 5.2 μM and 8.7 μM, respectively, more potent than previously reported hippolides. © 2014 by the authors; licensee MDPI.


Yang F.,Laboratory of Marine Drugs | Zhang H.-J.,Laboratory of Marine Drugs | Chen J.-T.,Laboratory of Marine Drugs | Tang H.-F.,PLA Fourth Military Medical University | And 3 more authors.
Natural Product Research | Year: 2011

Two new oxygenated sterols, 3β,24(S)-dihydroxycholesta-5,25-dien-7-one (1) and 3β,25-dihydroxycholesta-5,23-dien-7-one (2), were isolated from the marine bryozoan Bugula neritina. Their chemical structures were established on the basis of spectroscopic analysis. Both compounds exhibited cytotoxicity to three human cancer cell lines (HepG2, HT-29 and NCI-H460), with IC50 values between 22.58 and 53.41 μgmL -1. © 2011 Taylor & Francis.

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