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de Souza A.W.S.,Federal University of São Paulo | Keusseyan S.P.,Experimental Immuno rheumatology Laboratory of the Discipline of Rheumatology | da Silva N.P.,Unifesp | Sato E.I.,Unifesp | Andrade L.E.C.,Scripps Research Institute
Revista Brasileira de Reumatologia | Year: 2012

Objective: To study the association of anti-nucleosome (anti-NCS) antibodies in primary antiphospholipid syndrome (APS) and the development of systemic lupus erythematosus (SLE) during follow-up. Materials and methods: Thirty-six women with primary APS were evaluated prospectively for clinical features of systemic autoimmune diseases and for the presence of antiphospholipid antibodies, antinuclear antibodies and anti-NCS/chromatin antibodies. Results: After a mean follow-up period of 45.7 months, anti-NCS/chromatin antibodies were detected in only one patient (2.8%), who developed features of SLE including polyarthritis, lymphopenia, optic neuritis, multiple sclerosis-like lesions, and an autoantibody profi le suggestive of SLE. Conclusion: The frequency of anti-NCS/chromatin antibodies in primary APS patients is very low, and they may be associated with the development of SLE manifestations. © 2012 Elsevier Editora Ltda. All rights reserved.

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