Laboratory of Exercise Physiology

Brazil

Laboratory of Exercise Physiology

Brazil

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Ueda D.,Bunkyo University | Min S.-K.,Laboratory of Exercise Physiology | Nakazato K.,Laboratory of Exercise Physiology | Igawa S.,Nippon Sport Science University
International Journal of Sports Physiology and Performance | Year: 2013

Purpose: To examine the relationship between ACTN3 polymorphisms and level of athletic performance in Japanese wrestlers. Methods: The control group consisted of 243 healthy Japanese individuals. The authors divided 135 wrestlers into 3 groups based on their results in national or international competitions. They classified as elite 24 wrestlers who had placed in the top 8 in a world championship or participated in Olympic games, 28 wrestlers who had participated in world championships or become champions in Japan's national championships were classified as subelite, and 83 wrestlers were classified as national (N-W, ie, national-level wrestler). In addition, the authors combined the elite and subelite to form the classification international-level wrestlers (I-W). Results: The frequency of the null X allele and the XX genotype were significantly lower in the I-W group than in the control group. However, there was no significant difference in ACTN3 genotype or allele frequency between the N-W and control groups. The frequency of the ACTN3 XX genotype in the elite groups was lower than that of all groups, and a linear tendency was observed between ACTN3 XX genotype and athletic status. Conclusions: In conclusion, the data indicated that ACTN3 polymorphisms were related to athletic performance in Japanese wrestlers. © 2013 Human Kinetics, Inc.


Fonseca T.R.,Federal University of Minas Gerais | Botelho F.V.,Federal University of Minas Gerais | Botelho F.V.,Federal University of Uberlandia | De Lima D.C.,Federal University of Minas Gerais | And 4 more authors.
Journal of Exercise Physiology Online | Year: 2011

This study evaluated the effects of 6 weeks of swimming on lipid metabolism, oxidation resistance, and atherosclerosis in 6-week-old female apolipoprotein E-deficient mice (apoE -/-). The mice were divided into a control group (n=7) and a treatment group (n=7). Mice in the treatment group were required to swim 10 min·d -1, 5 d·wk -1 for 6 weeks (which was increased by 10 min·d -1 until the mice swam continuously for 1 hr). Plasma total cholesterol was evaluated before and after the experiment. Liver and fecal lipids, lipid oxidation resistance, and atherosclerotic area of thoracic and abdominal aorta were evaluated after euthanasia. Body weight, lipid metabolism, and lipid oxidation resistance were similar in both groups. Relative index was statistically decreased in the experimental group, thus suggesting that the apoE -/- mice that underwent the swimming exercise exhibited decreased atherosclerotic lesions in the aorta. However, the decrease was not due to changes in lipid metabolism or lipid oxidation resistance profile.


PubMed | University of Nevada, Las Vegas, Catholic University of Brasília, University of Brasilia, Laboratory of Exercise Physiology and Federal University of Mato Grosso do Sul
Type: Journal Article | Journal: Clinical physiology and functional imaging | Year: 2015

Both endothelial nitric oxide synthase (eNOS) gene polymorphism and nitric oxide (NO) are involved in important cardiovascular, muscular and inflammatory physiological mechanisms during ageing and response to exercise. The aim of this study was to investigate the NO kinetic response following an acute eccentric resistance exercise (ERE) session and the possible effect of the Glu298Asp eNOS gene polymorphism in elderly obese women. Eighty-seven women (age 69461years, body weight 749127kg, height 151960cm and BMI 32557kgm


Faoro V.,Laboratory of Exercise Physiology | Huez S.,Erasme University Hospital | Vanderpool R.,Free University of Colombia | Groepenhoff H.,VU University Amsterdam | And 7 more authors.
Journal of Applied Physiology | Year: 2014

Tibetans have been reported to present with a unique phenotypic adaptation to high altitude characterized by higher resting ventilation and arterial oxygen saturation, no excessive polycythemia, and lower pulmonary arterial pressures (Ppa) compared with other high-Altitude populations. How this affects exercise capacity is not exactly known. We measured aerobic exercise capacity during an incremental cardiopulmonary exercise test, lung diffusing capacity for carbon monoxide (DLCO) and nitric oxide (DLNO) at rest, and mean Ppa (mPpa) and cardiac output by echocardiography at rest and at exercise in 13 Sherpas and in 13 acclimatized lowlander controls at the altitude of 5,050 m in Nepal. In Sherpas vs. lowlanders, arterial oxygen saturation was 86 ± 1 vs. 83 ± 2% (mean ± SE; P = nonsignificant), mPpa at rest 19 ± 1 vs. 23 ± 1 mmHg (P < 0.05), DLCO corrected for hemoglobin 61 ± 4 vs. 37 ± 2 ml·min-1·mmHg-1 (P < 0.001), DLNO 226 ± 18 vs. 153 ± 9 ml·min -1·mmHg-1 (P < 0.001), maximum oxygen uptake 32 ± 3 vs. 28 ± 1 ml·kg-1·min-1 (P = nonsignificant), and ventilatory equivalent for carbon dioxide at anaerobic threshold 40 ± 2 vs. 48 ± 2 (P < 0.001). Maximum oxygen uptake was correlated directly to DLCO and inversely to the slope of mPpa-cardiac index relationships in both Sherpas and acclimatized lowlanders. We conclude that Sherpas compared with acclimatized lowlanders have an unremarkable aerobic exercise capacity, but with less pronounced pulmonary hypertension, lower ventilatory responses, and higher lung diffusing capacity. Copyright © 2014 the American Physiological Society.


Pierrat B.,Ecole Nationale Superieure des Mines de Saint - Etienne CMP | Molimard J.,Ecole Nationale Superieure des Mines de Saint - Etienne CMP | Navarro L.,Ecole Nationale Superieure des Mines de Saint - Etienne CMP | Avril S.,Ecole Nationale Superieure des Mines de Saint - Etienne CMP | And 2 more authors.
ASME 2012 11th Biennial Conference on Engineering Systems Design and Analysis, ESDA 2012 | Year: 2012

Knee orthotic devices are widely proposed by physicians and medical practitioners for preventive or therapeutic objectives in relation with their effects, usually known as to stabilize joint or restrict ranges of motion. The objectives of this work are to characterize the mechanical performance of knee orthoses using a Finite Element Model of a braced human leg. The interface properties of the model are calibrated against experimental data measured by full-field measurements of 3D displacement over the surface of a patient's leg. The results show that the mechanical action of knee braces is essentially limited by skin/fabric and skin/muscles sliding. Finally, the model leads to a better understanding of the knee/brace interaction, and of the role of the brace components on the stability of the injured knee. Thanks to this computational tool, novel brace designs can be tested and evaluated for an optimal mechanical efficiency of the devices. Copyright © 2012 by ASME.


da Cunha Nascimento D.,Catholic University of Brasília | da Cunha Nascimento D.,Centro Universitario | de Sousa N.M.F.,Laboratory of Exercise Physiology | de Sousa Neto I.V.,Catholic University of Brasília | And 10 more authors.
Aging Clinical and Experimental Research | Year: 2015

Background: Obesity, defined by an excess amount of body fat or a percent body fat higher than 30 % for women is a complex chronic disorder with multifactorial etiology and is accompanied by chronic low-grade inflammation, which results in elevated pro-inflammatory cytokines. Aims: The aim of this study was to compare muscle strength between high and low pro-inflammatory status in obese elderly women and to verify the relationship of IL-6 with muscle strength and fat-free mass. Methods: Eighty-nine elderly women (age 69.47 ± 6.07 years; body mass 64.70 ± 12.04 kg; height 1.52 ± 0.06 m; body mass index 27.78 ± 4.75 kg/m2) were divided into two groups: high and low inflammatory status for IL-6. Lower limb muscle strength was tested using bilateral leg extension with the ten repetitions maximum test, IL-6 was measured by ELISA and body composition by dual-energy X-ray absorptiometry. Results: Women classified from the high pro-inflammatory status presented lower relative muscle strength (P = 0.056) when compared with the low inflammatory status group, with no differences for absolute muscle strength (P = 0.18). There was a significant negative correlation of IL-6 with relative muscle strength (P = 0.03, R = −0.22) and a considerable trend toward significance (P = 0.06, R = −0.19) and negative association with fat-free mass (P = 0.84, R = −0.02). Conclusions: This study provides insights that a high pro-inflammatory status in sedentary obese elderly women might impair muscle strength and negatively affect fat-free mass. Thus, elderly women classified with high pro-inflammatory status for IL-6 should receive further health care attention to prevent this deleterious condition. © 2015, Springer International Publishing Switzerland.


Tibana R.A.,Catholic University of Brasília | Da Cunha Nascimento D.,Catholic University of Brasília | De Sousa N.M.F.,Laboratory of Exercise Physiology | De Souza V.C.,Catholic University of Brasília | And 9 more authors.
PLoS ONE | Year: 2014

These data describe the effects of combined aerobic plus resistance training (CT) with regards to risk factors of metabolic syndrome (MetS), quality of life, functional capacity, and pro- and anti-inflammatory cytokines in women with MetS. In this context, thirteen women (35.4±6.2 yr) completed 10 weeks of CT consisting of three weekly sessions of ∼60 min aerobic training (treadmill at 65-70% of reserve heart rate, 30 min) and resistance training (3 sets of 8-12 repetitions maximum for main muscle groups). Dependent variables were maximum chest press strength; isometric hand-grip strength; 30 s chair stand test; six minute walk test; body mass; body mass index; body adiposity index; waist circumference; systolic (SBP), diastolic and mean blood pressure (MBP); blood glucose; HDL-C; triglycerides; interleukins (IL) 6, 10 and 12, osteoprotegerin (OPG) and serum nitric oxide metabolite (NOx); quality of life (SF-36) and Z-Score of MetS. There was an improvement in muscle strength on chest press (p = 0.009), isometric hand-grip strength (p = 0.03) and 30 s chair stand (p = 0.007). There was a decrease in SBP (p = 0.049), MBP (p = 0.041), Z-Score of MetS (p = 0.046), OPG (0.42±0.26 to 0.38±0.19 ng/mL, p<0.05) and NOx (13.3± 2.3 μmol/L to 9.1±2.3 μmol/L; p<0.0005). IL-10 displayed an increase (13.6±7.5 to 17.2±12.3 pg/mL, p<0.05) after 10 weeks of training. Combined training also increased the perception of physical capacity (p = 0.011). This study endorses CT as an efficient tool to improve blood pressure, functional capacity, quality of life and reduce blood markers of inflammation, which has a clinical relevance in the prevention and treatment of MetS. © 2014 PLOS ONE.


PubMed | Catholic University of Brasília, University of Nevada, Las Vegas, Laboratory of Exercise Physiology and Federal University of Mato Grosso do Sul
Type: Journal Article | Journal: Aging clinical and experimental research | Year: 2015

Obesity, defined by an excess amount of body fat or a percent body fat higher than 30% for women is a complex chronic disorder with multifactorial etiology and is accompanied by chronic low-grade inflammation, which results in elevated pro-inflammatory cytokines.The aim of this study was to compare muscle strength between high and low pro-inflammatory status in obese elderly women and to verify the relationship of IL-6 with muscle strength and fat-free mass.Eighty-nine elderly women (age 69.476.07years; body mass 64.7012.04kg; height 1.520.06m; body mass index 27.784.75kg/m(2)) were divided into two groups: high and low inflammatory status for IL-6. Lower limb muscle strength was tested using bilateral leg extension with the ten repetitions maximum test, IL-6 was measured by ELISA and body composition by dual-energy X-ray absorptiometry.Women classified from the high pro-inflammatory status presented lower relative muscle strength (P=0.056) when compared with the low inflammatory status group, with no differences for absolute muscle strength (P=0.18). There was a significant negative correlation of IL-6 with relative muscle strength (P=0.03, R=-0.22) and a considerable trend toward significance (P=0.06, R=-0.19) and negative association with fat-free mass (P=0.84, R=-0.02).This study provides insights that a high pro-inflammatory status in sedentary obese elderly women might impair muscle strength and negatively affect fat-free mass. Thus, elderly women classified with high pro-inflammatory status for IL-6 should receive further health care attention to prevent this deleterious condition.


PubMed | Catholic University of Brasília, University of Brasilia, Laboratory of Exercise Physiology and University of Nevada, Las Vegas
Type: Clinical Trial | Journal: PloS one | Year: 2014

These data describe the effects of combined aerobic plus resistance training (CT) with regards to risk factors of metabolic syndrome (MetS), quality of life, functional capacity, and pro- and anti-inflammatory cytokines in women with MetS. In this context, thirteen women (35.4 6.2 yr) completed 10 weeks of CT consisting of three weekly sessions of ~60 min aerobic training (treadmill at 65-70% of reserve heart rate, 30 min) and resistance training (3 sets of 8-12 repetitions maximum for main muscle groups). Dependent variables were maximum chest press strength; isometric hand-grip strength; 30 s chair stand test; six minute walk test; body mass; body mass index; body adiposity index; waist circumference; systolic (SBP), diastolic and mean blood pressure (MBP); blood glucose; HDL-C; triglycerides; interleukins (IL) 6, 10 and 12, osteoprotegerin (OPG) and serum nitric oxide metabolite (NOx); quality of life (SF-36) and Z-Score of MetS. There was an improvement in muscle strength on chest press (p = 0.009), isometric hand-grip strength (p = 0.03) and 30 s chair stand (p = 0.007). There was a decrease in SBP (p = 0.049), MBP (p = 0.041), Z-Score of MetS (p = 0.046), OPG (0.42 0.26 to 0.38 0.19 ng/mL, p<0.05) and NOx (13.3 2.3 mol/L to 9.1 2.3 mol/L; p<0.0005). IL-10 displayed an increase (13.6 7.5 to 17.2 12.3 pg/mL, p < 0.05) after 10 weeks of training. Combined training also increased the perception of physical capacity (p = 0.011). This study endorses CT as an efficient tool to improve blood pressure, functional capacity, quality of life and reduce blood markers of inflammation, which has a clinical relevance in the prevention and treatment of MetS.


Bonganha V.,University of Campinas | Bonganha V.,Laboratory of Exercise Physiology | Conceicao M.S.,University of Campinas | Conceicao M.S.,Laboratory of Exercise Physiology | And 4 more authors.
Revista Brasileira de Medicina do Esporte | Year: 2011

Introduction: The physical changes from menopause such as decrease in lean mass (LM), growth and redistribution of body fat and decrease in resting energy expenditure, contribute to the increase in body size and subsequent increase in total body mass. Accordingly, the recognized benefits of resistance training (RT) are not only linked to increased strength and muscle hypertrophy, but also to body composition and consequently to the resting metabolic rate (RMR). Objective: To evaluate the RMR response after 16 weeks of RT in postmenopausal women. Methods: 28 female volunteers subdivided into two groups participated in the study: training (TG n = 17) and control (CG n = 11). The RT program was conducted in three weekly sessions, on alternate days and lasted approximately 60 min/session during 16 weeks. Load intensity was determined by means of target area of maximum repetitions, with weekly load readjustment. The oxygen consumption (VO2) and carbon dioxide production (VCO2), using open circuit indirect calorimetry was used to calculate the RMR according to Weir equation (1949). Statistical analysis: statistical package Bioestat, version 5.0, with a significance level of p <0.05 was used. Results: There was significant increase of the LM values and muscle strength in TG only. No significant differences were found for the RMR values after intervention for both groups. Conclusion: The RT program of 16 weeks was effective in promoting changes in body composition and muscle strength in postmenopausal women; nevertheless, there was not change in RMR after intervention.

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