Laboratory of Histology Embryology

Alexandroúpoli, Greece

Laboratory of Histology Embryology

Alexandroúpoli, Greece
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Athanasios Z.,Democritus University of Thrace | Pavlos P.,Laboratory of Forensic science | Valeria K.,Laboratory of Forensic science | Anastasia P.,Democritus University of Thrace | And 3 more authors.
Review of Clinical Pharmacology and Pharmacokinetics, International Edition | Year: 2017

Vitamin D is a fat-soluble chemical substance that plays a significant role in many systems of human body. More specifically, contributes in regulation of calcium and phosphate ions homeostasis in human's bloodstream in cooperation with Parathormone ( PTH ). The significant role of Vitamin D relies on the regulation of calcium and phosphate ions concentration in bloodstream. Vitamin D promotes the absorption of calcium, magnesium, iron, phosphate ions and zinc by intestine. In this study we describe the structure , the synthesis and the role of Vitamin D in many systems of human body. © 2017 PHARMAKON-Press.


Kaprara A.,Anticancer Hospital Theagenio | Pazaitou-Panayiotou K.,Anticancer Hospital Theagenio | Chemonidou M.C.,Democritus University of Thrace | Constantinidis T.C.,Laboratory of Hygiene | And 6 more authors.
Neuropeptides | Year: 2010

The hypothalamic neuropeptide corticotropin releasing factor (CRF) has been found in several types of human cancer, where its biological role is not clarified. In experimental models of breast cancer CRF has been shown to exert anti-proliferative and other actions. Aim of the present study was to describe the expression of the two types of CRF receptors CRF1 and CRF2 in human breast tumors. Receptor expression was studied in breast biopsies from patients diagnosed for primary breast adenocarcinoma, obtained from the tumor and the adjacent benign tissue. Gene expression levels were evaluated by real-time PCR following reverse transcription of total RNA extracts. CRF1 transcripts were found in 23.1% of benign and in 23.1% of malignant biopsies. CRF2(a) was found in 22.2% of benign and 36.0% of malignant biopsies. Transcript levels of both receptors did not differ significantly between cancer and benign biopsies from the same tumor. No correlation was found between CRF receptor expression and patient histo/clinicopathological characteristics. Histological mapping using immunohistochemistry revealed positive CRF1 immunostaining in the cancerous implants and breast ducts, whereas CRF2 immunoreactivity was localized mainly in the perineural invasions. In conclusion, both CRF receptors were found in breast cancer and the respective benign adjacent tissue. The two CRF receptor proteins presented distinct distribution and subcellular localization, pointing into differing biological roles. CRF receptors could serve as targets of endogenous ligands expressed in the tumor microenvironment, regulating cancer growth. © 2010 Elsevier Ltd.

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