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Silla L.M.R.,Hematology and Bone Marrow Transplantation | Silla L.M.R.,Federal University of Rio Grande do Sul | Silla L.M.R.,Amigos y Amigos | Silla L.M.R.,Laboratory of Cell Culture and Molecular Analysis of Hematopoietic Cells | And 24 more authors.
PLoS ONE | Year: 2013

This population-based study was designed to detect the prevalence of anemia in a healthy population of children (18 months to 7 years) and women (14 to 30 years) tested in 2006-2007 in the state of Rio Grande do Sul, Brazil as part of an effort to tackle this massive problem that still affects so many people in the XXI century. Anemia was defined according to the WHO. Capillary blood was measured and socioeconomic status was determined according to the Brazilian Association of Market Research Agencies. The median prevalence of anemia in 2198 children was 45.4% and in 1999 women 36.4%. Anemia decreased with age during childhood; although significantly more prevalent in lower classes individuals, it was also high in the upper classes. There are indirect evidences that the lack of iron supplementation and/or iron fortified food may play a role in it. Professionals and society wise measures of education have to be implemented in order to address possible biologic factors involved in childhood psychosocial development in southern Brazil. © 2013 Silla et al.


Rigoni L.,CTC RS | Rigoni L.,Federal University of Rio Grande do Sul | Scroferneker M.L.,Federal University of Rio Grande do Sul | Pitombeira B.S.,CTC RS | And 22 more authors.
Transplantation Proceedings | Year: 2015

Introduction Early lymphocyte recovery after allogeneic hematopoietic stem cell transplantation (HSCT) is related to the prevention of serious infections and the clearing of residual tumor cells. Methods We analyzed the absolute lymphocyte count at 20 (D+20) and 30 (D+30) days after HSCT in 100 patients with malignant hematologic diseases and correlated with the risk of transplant-related mortality, overall survival (OS), disease-free survival (DFS), nonrelapsed mortality (NRM), and risk of infection. Results Patients presenting with lymphocyte counts of <300 × 103/μL on D+30 have a 3.76 times greater risk of death in <100 days. Over a medium follow-up of 20 months OS, DFS, and NRM were similar between the groups. Conclusion In our group of patients delayed lymphocyte recovery after HSCT was a predictor of early death post-HSCT. © 2015 Elsevier Inc. All rights reserved.

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