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Scattolin S.,University of Padua | Gaio P.,University of Padua | Betto M.,University of Padua | Palatron S.,University of Padua | And 4 more authors.
Journal of Perinatology | Year: 2013

Objective:To study the possible influences of amino acid (AA) intakes on growth and bone status in preterms.Study Design:Newborns, weighing <1250 g, received standard (S) or higher (H) parenteral AA intakes (3 or 4 g kg -1 per day). Anthropometry, biochemistry and quantitative ultrasound (metacarpus bone transmission time (mcBTT), in μs) were measured prospectively.Result:A total of 55 patients in group S and 60 in group H were studied. Significantly better growth rate was found in the H group during the study without signs of intolerance. We found a significant decrease in mcBTT from birth to 21 days in the H group; nonetheless, mcBTT at 36 weeks of gestational age significantly positively correlated with early AA and energy intakes. A significant positive correlation between mcBTT and lower limb length (LLL) at 21 days was found.Conclusion:Early higher AA intakes improved growth without short-term AA intolerance. Nutritional parameters could influence bone growth. LLL was the anthropometric parameter that best correlated to bone status. © 2013 Nature America, Inc. All rights reserved.

Betto M.,University of Padua | Gaio P.,University of Padua | Ferrini I.,University of Padua | De Terlizzi F.,Laboratory of Clinical Biophysics | And 4 more authors.
Journal of Maternal-Fetal and Neonatal Medicine | Year: 2014

Objective: To assess bone status in preterm infants with quantitative ultrasound and to search for biochemical markers of bone health. Methods: Metacarpus bone transmission time (mcBTT) was prospectively performed during hospitalization, together with biochemical and clinical outcomes analysis. Results: 154 patients were studied. At 3rd week of life mcBTT positively correlated with serum phosphate. Urinary excretion of calcium and phosphate were assessed in a subgroup of 55 patients: on day 21 mcBTT positively correlated with phosphaturia, negatively with calciuria. Gestational age (GA), weight and length at 3rd week and at 36 weeks of GA correlated positively with mcBTT. We found negative correlation between mcBTT at 3rd week and days of parenteral nutrition, mechanical ventilation period and days to reach 1800 g. Conclusions: Serum phosphate, phosphaturia and calciuria correlate most with mcBTT. Further studies are necessary to verify the possible influence of early bone status on future bone health. © 2014 Informa UK Ltd.

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