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Byelinska I.,Taras Shevchenko National University | Byelinska I.,Laboratory of Biologically Active Substances | Byelinska I.,Ukrainian Academy of Sciences | Rybalchenko T.,Taras Shevchenko National University | And 14 more authors.
Annales Universitatis Mariae Curie-Sklodowska, Sectio DDD: Pharmacia | Year: 2010

The aim of the study was to investigate the effect of novel mixed-metal complex [Cu(dmen)2] [Fe(CN)5(NO)] (dmen=N,N- dimethylethylenediamme) (code KL447) on dynamics of serum iron and copper m the experimental anemia of rats. At the peak of anemia the serum iron levels were shown to decrease and the copper level - to increase and these retained during 20 days of the recovery period m the anemic group. KL447 increases serum iron and copper levels. These results indicate that the mixed-metal Cu/Fe complex causes the recovery of the serum iron levels and increases the serum copper levels in the experimental anemia of rats and it could be a potential substance for stimulation of erythropoiesis.

Denev P.N.,Laboratory of Biologically Active Substances | Kratchanov C.G.,Laboratory of Biologically Active Substances | Ciz M.,Academy of Sciences of the Czech Republic | Lojek A.,Academy of Sciences of the Czech Republic | Kratchanova M.G.,Vitanea Ltd.
Comprehensive Reviews in Food Science and Food Safety | Year: 2012

Black chokeberry (Aronia melanocarpa) is a distinctive berry with a high content of polyphenol compounds and possesses one of the highest in vitro antioxidant activities among fruits. The bioavailability of aronia polyphenols seems to be low, but there is ample evidence for chokeberry health benefits including antidiabetic, cardioprotective, hepatoprotective, antimutagenic, and anticarcinogenic effects. This review presents the available information for the bioavailability and antioxidant activity of chokeberry polyphenols and explains the possible mechanisms of action in vivo in the prevention and treatment of oxidative stress-related diseases. The review shows the available data for chokeberry antioxidant activity in vitro, in isolated cells and cell lines, and in vivo, in both human subjects and animals. It is evident that in vivo antioxidant action of chokeberry extends far beyond radical scavenging and includes suppression of reactive oxygen and nitrogen species formation, inhibition of prooxidant enzymes, restoration of antioxidant enzymes, and probably cellular signaling to regulate the level of antioxidant compounds and enzymes. The original contribution of this work is that it compiles the available information up to date and outlines the gaps and future directions in the assessment of chokeberry antioxidant action in vivo. © 2012 Institute of Food Technologists®.

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