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Ciofani G.,Sant'Anna School of Advanced Studies | Danti S.,University of Pisa | Moscato S.,University of Pisa | Albertazzi L.,CNR Institute of Neuroscience | And 6 more authors.
Colloids and Surfaces B: Biointerfaces | Year: 2010

Nanoscale structures and materials have been explored in many biological applications because of their extraordinary novel properties. Here we propose a study of cellular interactions with barium titanate nanoparticles, an interesting ceramic material that has received a lot of interest in the nanotechnology research, but without any attention about its biological potential. We introduced for the first time an efficient method for the preparation of stable aqueous dispersions of barium titanate nanoparticles, characterized with FIB, TEM and AFM imaging, light scattering, Z-potential and UV/vis analysis. Finally, we presented a systematic study of short-term cytotoxicity of the prepared dispersion based both on quantitative (metabolism, proliferation) and qualitative (apoptosis, viability, differentiation) assays. © 2009 Elsevier B.V. All rights reserved.


Puppi D.,Laboratory of Bioactive Polymeric Materials for Biomedical and Environmental Applications BIOlab | Puppi D.,University of Pisa | Dinucci D.,Laboratory of Bioactive Polymeric Materials for Biomedical and Environmental Applications BIOlab | Dinucci D.,University of Pisa | And 11 more authors.
Journal of Bioactive and Compatible Polymers | Year: 2011

Three-dimensional wet-spun microfibrous meshes of a star poly(ε-caprolactone) were developed as potential scaffolds endowed with antimicrobial activity. The in vitro release kinetics of the meshes, under physiological conditions, was initially fast and then a sustained release for more than one month was observed. Cell cultures of a murine pre-osteoblast cell line showed good cell viability and adhesion on the wet-spun star poly(ε-caprolactone) fiber scaffolds. These promising results indicate a potential application of the developed meshes as engineered bone scaffolds with antimicrobial activity. © Authors 2011.


Puppi D.,Laboratory of Bioactive Polymeric Materials for Biomedical and Environmental Applications BIOlab | Puppi D.,University of Pisa | Detta N.,Laboratory of Bioactive Polymeric Materials for Biomedical and Environmental Applications BIOlab | Detta N.,University of Pisa | And 8 more authors.
Macromolecular Bioscience | Year: 2010

We have developed three-dimensional electrospun microfibrous meshes of a novel star branched three-arm poly(ε-caprolactone) (*PCL) as potential scaffolds for tissue engineering applications. The processing conditions required to obtain uniform fibers were optimized by studying their influence on fiber morphology and size. Polymer molecular weight and solution feed rate influenced both the mesh microstructure and the tensile properties of the developed mats. Electrospun samples were also tested for their mechanical properties in wet conditions, showing higher yield strength and strain in comparison to that observed in dry conditions. Cell culture experiments employing MC3T3-E1 osteoblast like cells showed good cell viability adhesion and collagen production on the *PCL scaffolds. (Figure Presented) © 2010 Wiley-VCH Verlag GmbH & Co. KGaA.

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