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Busch F.,Ludwig Maximilians University of Munich | Mobasheri A.,University of Nottingham | Shayan P.,Investigating Institute of Molecular Biological System Transfer | Lueders C.,Laboratory for Tissue Engineering | And 2 more authors.
Journal of Biological Chemistry | Year: 2012

Background: Resveratrol has been proposed to have beneficial health effects due to its anti-inflammatory properties. Results: Resveratrol suppressed IL-1β-induced activation of NF-κB and PI3K in a dose- and time-dependent manner. Conclusion: Anti-inflammatory effects of resveratrol may be mediated at least in part through inhibition/deacetylation of PI3K and NF-κB. Significance: Activated Sirt-1 plays an essential role in anti-inflammatory effects of resveratrol. © 2012 by The American Society for Biochemistry and Molecular Biology, Inc.

Reichardt A.,Laboratory for Tissue Engineering | Arshi A.,RWTH Aachen | Schuster P.,RWTH Aachen | Polchow B.,Laboratory for Tissue Engineering | And 5 more authors.
Journal of Biomaterials and Tissue Engineering | Year: 2012

Polymers composed of polyglycolide (PGA) or polylactide (PLA) have been studied in multiple research projects for orthopedic applications, cardiovascular tissue engineering (TE) and drug delivery systems. In a recent TE study we generated and analyzed custom-made nonwovens composed of PGA, PLA, a composite structure of PLA/PGA, and the copolymer PLG regarding the behavior of cells when seeded onto these structures. The fabrication of the individual nonwovens was optimized for this study. PGA nonwovens revealed notable cell compatibility, with large amounts of extracellular matrix proteins. Unfortunately, rapid shrinking induced by labored hydrolytic degradation and failing resistibility to cells was detected. Incorporation of additional, long-living material, e.g., PLA was essential for the fabrication of an applicable TE substitute. The best results, combining cell compatibility and longevity of the cell-matrix construct, were achieved using the PLA/PGA composite. The durability of PLA/PGA composite structures makes them promising for use in such regions of increased load, as the heart and particularly for the tissue engineering of cardiovascular structures such as heart valves. © 2012 American Scientific Publishers. All rights reserved.

Hutchinson I.D.,Laboratory for Tissue Engineering | Moran C.J.,Sports Medicine and Shoulder Service | Potter H.G.,Hospital for Special Surgery | Warren R.F.,Sports Medicine and Shoulder Service | Rodeo S.A.,Sports Medicine and Shoulder Service
American Journal of Sports Medicine | Year: 2014

Over the past 2 decades there has been a profound shift in our perception of the role of the meniscus in the knee joint. Orthopaedic opinion now favors salvaging and restoring the damaged meniscus where possible. Basic science is characterizing its form (anatomy) and functionality (biological and biomechanical) in an attempt to understand the effect of meniscal injury and repair on the knee joint as a whole. The meniscus is a complex tissue and has warranted extensive basic science translational, and clinical research to identify techniques to augment healing and even replace the meniscus. The application of quantitative magnetic resonance image sequencing to the meniscus and articular cartilage of the affected compartment promises to add a quantifiable outcome measure to the body of clinical evidence that supports restoration of the meniscus. This article discusses the recent advances and outcomes in the pursuit of meniscal restoration with particular focus on the use of augmentation strategies in meniscal repair, meniscal imaging, and translational strategies. © 2013 The Author(s).

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