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Tuguz A.R.,Laboratory for Immunogenetics of Research Institute of Complex Problems of Adygei State University | Anokhina E.N.,Laboratory for Immunogenetics of Research Institute of Complex Problems of Adygei State University | Muzhenya D.V.,Laboratory for Immunogenetics of Research Institute of Complex Problems of Adygei State University | Rudenko K.A.,Laboratory for Immunogenetics of Research Institute of Complex Problems of Adygei State University
Bulletin of Experimental Biology and Medicine | Year: 2015

Association of three polymorphisms (1082G/A, 819C/T, and 592C/A) of the promotor region of the anti-inflammatory IL-10 gene with malignancy of female reproductive organs was revealed by SNP (single nucleotide polymorphism) method in ethnic groups of Adygei Republic. Breast cancer, cervical cancer, and cancer of the uterine corpus are associated with allele 592A (р=0.042) in Circassians and with polymorphism 819T in Russians (р=0.046). Irrespective of the ethnicity, allele 819T was signifi cantly more often (р<0.05) detected in prevalent forms of breast cancer involving regional lymph nodes. 1082G polymorphism is associated with low-differentiated adenocarcinoma. In women of Adygei Republic, ATA/GCA gaplotypes are associated with high risk factors for breast cancer. © 2015, Springer Science+Business Media New York. Source

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