Laboratorios Del Dr. Esteve SA

Barcelona, Spain

Laboratorios Del Dr. Esteve SA

Barcelona, Spain
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The present invention relates to compounds having dual pharmacological activity towards both the sigma () receptor, and the -opiod receptor and more particularly to diazaspiro undecane compounds having this pharmacological activity, to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use in therapy, in particular for the treatment of pain.


Patent
Laboratorios del Dr. Esteve S.A. | Date: 2017-05-10

The present invention relates to new tricyclic triazolic compounds having a great affinity for sigma receptors, especially sigma-1 receptors, as well as to the process for the preparation thereof, to compositions comprising them, and to their use as medicaments.


Patent
Laboratorios del Dr. Esteve S.A. | Date: 2017-03-22

The present invention provides new adenoassociated virus vectors and pharmaceutical compositions containing the same for the treatment of lysosomal storage disorders and specially, for the treatment of mucopolysaccharidoses Type IIIB.


The present invention relates to compounds of general formula (I) having dual pharmacological activity towards both the sigma () receptor, and the -opiod receptor and more particularly to diazaspiro undecane compounds having this pharmacological activity, to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use in therapy, in particular for the treatment of pain.


Patent
Laboratorios Del Dr Esteve S.A., Fundacio Privada Institute Of Recerca Of La Sida Ca, Catalan Institution for Research, Advanced Studies and University of Washington | Date: 2017-03-20

The invention relates to peptides comprising part or all of a conserved element within a Center-of-Tree (COT) sequence derived from a family of polypeptides encoded by naturally occurring variants of HIV. The invention also relates to immunogenic compositions and vaccines comprising said peptides. The invention also relates to methods for the identification of HIV controller patients based on the detection of the T cells of the patient to mount a cytotoxic T cell response against said peptides and to methods for the identification of immunogenic peptides within a family of variant polypeptides.


Patent
Laboratorios del Dr. Esteve S.A. and University of Washington | Date: 2017-08-16

The invention relates to peptides comprising part or all of a conserved element within a Center-of Tree (COT) sequence derived from a family of polypeptides encoded by naturally occurring variants of HIV. The invention also relates to immunogenic compositions and vaccines comprising said peptides. The invention also relates to methods for the identification of HIV controller patients based on the detection of the T cells of the patient to mount a cytotoxic T cell response against said peptides and to methods for the identification of immunogenic peptides within a family of variant polypeptides.


The present invention relates to compounds having dual pharmacological activity towards both the sigma () receptor, and the -opioid receptor and more particularly to diazaspiro undecane compounds having this pharmacological activity, to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use in therapy, in particular for the treatment of pain. (formula 1) wherein Y is (formula 2) or (formula 3) n is 1 or 2; q is 1, 2, 3, 4, 5 or 6; X is a bond, -C(O)O-, -C(0)NR 8-, -C(O)-, -0- or -C(R 4R 4.)-; R 1is C(0)R 5or S(O) 2R 5.


Patent
Laboratorios Del Dr. Esteve S.A. | Date: 2016-08-09

The present invention relates to co-crystals of tramadol and co-crystal formers selected from NSAIDs/coxibs, processes for preparation of the same and their uses as medicaments or in pharmaceutical formulations, more particularly for the treatment of pain.


Patent
Laboratorios Del Dr. Esteve S.A. | Date: 2017-04-26

The present invention relates to oral pharmaceutical compositions comprising co-crystals of tramadol and celecoxib, processes for preparation of the same and their use as medicaments, more particularly for the treatment of pain.


The present invention refers to the use of compounds binding to the sigma receptor for the treatment or prevention of neuropathic pain resulting from chemotherapy.

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