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Castel Guelfo di Bologna, Italy

Viceconti M.,Laboratorio Of Tecnologia Medica
Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences | Year: 2011

The growing importance of predictive models in biomedical research raises some concerns on the correct methodological approach to the falsification of such models, as they are developed in interdisciplinary research contexts between physics, biology and medicine. In each of these research sectors, there are established methods to develop cause-effect explanations for observed phenomena, which can be used to predict: epidemiological models, biochemical models, biophysical models, Bayesian models, neural networks, etc. Each research sector has accepted processes to verify how correct these models are (falsification). But interdisciplinary research imposes a broader perspective, which encompasses all possible models in a general methodological framework of falsification. The present paper proposes a general definition of 'scientific model' that makes it possible to categorize predictive models into broad categories. For each of these categories, generic falsification strategies are proposed, except for the so-called 'abductive' models. For this category, which includes artificial neural networks, Bayesian models and integrative models, the definition of a generic falsification strategy requires further investigation by researchers and philosophers of science. This journal is © 2011 The Royal Society.


Testi D.,SCS B3C | Quadrani P.,Supercomputing Center | Viceconti M.,Laboratorio Of Tecnologia Medica
Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences | Year: 2010

Every research laboratory has a wealth of biomedical data locked up, which, if shared with other experts, could dramatically improve biomedical and healthcare research. With the PhysiomeSpace service, it is now possible with a few clicks to share with selected users biomedical data in an easy, controlled and safe way. The digital library service is managed using a client-server approach. The client application is used to import, fuse and enrich the data information according to the PhysiomeSpace resource ontology and upload/download the data to the library. The server services are hosted on the Biomed Town community portal, where through a web interface, the user can complete the metadata curation and share and/or publish the data resources. A search service capitalizes on the domain ontology and on the enrichment of metadata for each resource, providing a powerful discovery environment. once the users have found the data resources they are interested in, they can add them to their basket, following a metaphor popular in e-commerce web sites. When all the necessary resources have been selected, the user can download the basket contents into the client application. The digital library service is now in beta and open to the biomedical research community. © 2010 The Royal Society.


Affatato S.,Laboratorio Of Tecnologia Medica
Artificial Organs | Year: 2016

The problems associated with prosthetic failure and revision surgery still constitute the main clinical problem of prosthetic surgery. The objective of wear evaluation is to determine the wear rate and its dependence on the test conditions. To obtain realistic results, a wear test can be performed to reproduce in vivo working conditions and compare the wear characteristics of various total knee prostheses designs. At the state of the art, two simulation concepts are available and defined in ISO 14243 standards series. In both these guidelines, level walking is the sole activity of daily living that is represented for testing. With so many variables and so many sources of error and the sensitivity of the output to these errors, can the motion determined in the simulator be representative of the in vivo motion? This article goes beyond the current status of these knee simulations comparing literature results. © 2016 Wiley Periodicals, Inc. and International Center for Artificial Organs and Transplantation.


Viceconti M.,Laboratorio Of Tecnologia Medica
Proceedings of the 2011 20th IEEE International Workshops on Enabling Technologies: Infrastructure for Collaborative Enterprises, WETICE 2011 | Year: 2011

The Virtual Physiological Human (VPH) is an international research initiative, which aims to develop a framework of methods and technologies enabling an integrative investigation of the human physiology and pathology. The term integrative indicates the need to overcome the limitations of the reductionist approach, attempting to capture the emergences due to systemic interaction between space-time scales, organ systems, but also academic disciplines. In this brief presentation of the VPH initiative and of its early results we argue that the VPH is first and foremost an attempt to develop an effective environment for collaborative modeling and simulation. © 2011 IEEE.


Affatato S.,Laboratorio Of Tecnologia Medica | Ruggiero A.,University of Salerno | Merola M.,University of Salerno
Composites Part B: Engineering | Year: 2015

Wear of total hip prosthesis is a significant clinical problem that nowadays involves a growing number of patients. To acquire further knowledge on the tribological phenomena that involve hip prosthesis, wear tests are conducted on new biomaterials to increase materials life in orthopaedic implants. Advances in biomaterials for biomedical purposes have enhanced in the last years evolving in new improved ceramic and polymeric materials producing the so-called composite materials. This paper aims to review the evolution and the current state of the art of the ceramics composites and polymers commonly used in orthopaedic field as hip joint implants. This is specified through a schematic overview by describing, in particular, the evolution of various composites materials. The authors propose commentary on the evolution and current use of biomaterials for orthopaedic application on the evolution and actually used biomaterials for orthopaedic applications. © 2015 Elsevier Ltd

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