Laboratorio Of Productos Naturales

Antofagasta, Chile

Laboratorio Of Productos Naturales

Antofagasta, Chile
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Payo-Hill A.L.,Institute Ecologia Y Sistematica | Sandoval-Lopez D.,Institute Ecologia Y Sistematica | Spengler-Salabarria I.,Laboratorio Of Productos Naturales | Rastrelli L.,University of Salerno
Natural Product Communications | Year: 2013

Two new 8,14-dihydromorphinandienone alkaloids were isolated from the dried leaves of Croton micradenus. Spectroscopic analysis established their structures as trans B/C-4-hydroxy-3,6-dimethoxy-5,6-didehydromorphinan-7-one and cis B/C-4-hydroxy-3,6-dimethoxy-5,6-didehydromorphinan-7-one to which we have given the name of norocobotrine and nildahilline.

Bruno-Colmenarez J.,Venezuelan Institute for Scientific Research | Amaro-Luis J.M.,Laboratorio Of Productos Naturales | Delgado J.M.,University of Los Andes, Venezuela | Diaz de Delgado G.,University of Los Andes, Venezuela
Powder Diffraction | Year: 2017

Ambroperuvin is a new pseudoguaianolide isolated from Ambrosia peruviana Willd., a plant used in traditional medicine in Venezuela. The analysis of the X-ray powder pattern being reported led to an orthorhombic unit cell with space group P212121 and cell parameters a = 15.999(6) Å, b = 11.263(2) Å, c = 9.112(2) Å. No detectable impurities were observed. Copyright © International Centre for Diffraction Data 2017

Molina-Salinas G.M.,Grupo Mexico | Molina-Salinas G.M.,Instituto Mexicano del Seguro Social | Borquez J.,Laboratorio Of Productos Naturales | Ardiles A.,Laboratorio Of Productos Naturales | And 5 more authors.
Fitoterapia | Year: 2010

The antituberculosis activity of 14 natural azorellane and mulinane diterpenoids isolated from Azorella compacta, Azorella madreporica, Mulinum crassifolium, and Laretia acaulis, together with eight semisynthetic derivatives, was evaluated against two Mycobacterium tuberculosis strains. The natural azorellanes azorellanol (3) and 17-acetoxy-13-α-hydroxyazorellane (6), and the semisynthetic mulinanes 13-hydroxy-mulin-11-en-20-oic-acid methyl ester (13) and mulinenic acid methyl ester (23), showed the strongest activity, with MIC values of 12.5 μg/mL against both strains. The methylated derivatives 13-hydroxy-mulin-11-en-20-oic-acid methyl ester (13), mulin-11,13-dien-20-oic acid methyl ester (15) and mulinenic acid methyl ester (23) proved to be more active than the parent compounds. © 2009 Elsevier B.V. All rights reserved.

Brito A.,Laboratorio Of Productos Naturales | Areche C.,University of Chile | Sepulveda B.,Viña del Mar University | Kennelly E.J.,City University of New York | Simirgiotis M.J.,Laboratorio Of Productos Naturales
Molecules | Year: 2014

The anthocyanin composition and HPLC fingerprints of six small berries endemic of the VIII region of Chile were investigated using high resolution mass analysis for the first time (HR-ToF-ESI-MS). The antioxidant features of the six endemic species were compared, including a variety of blueberries which is one of the most commercially significant berry crops in Chile. The anthocyanin fingerprints obtained for the fruits were compared and correlated with the antioxidant features measured by the bleaching of the DPPH radical, the ferric reducing antioxidant power (FRAP), the superoxide anion scavenging activity assay (SA), and total content of phenolics, flavonoids and anthocyanins measured by spectroscopic methods. Thirty one anthocyanins were identified, and the major ones were quantified by HPLC-DAD, mostly branched 3-O-glycosides of delphinidin, cyanidin, petunidin, peonidin and malvidin. Three phenolic acids (feruloylquinic acid, chlorogenic acid, and neochlorogenic acid) and five flavonols (hyperoside, isoquercitrin, quercetin, rutin, myricetin and isorhamnetin) were also identified. Calafate fruits showed the highest antioxidant activity (2.33 ± 0.21 μg/mL in the DPPH assay), followed by blueberry (3.32 ± 0.18 μg/mL), and arrayán (5.88 ± 0.21), respectively. © 2014 by the authors.

A mixture of long-chain acyl polyamines (baptized as cinachyramides) was isolated from the marine sponge Cinachyrella kuekenthali, with a yield of 4.24% from the crude extract. The mixture of cinachyramides exhibited an antibacterial activity that was more pronounced against Gram positive bacteria with half lethal concentration (LC50) values of 2.58, 5.91, 16.40 and 56.40 μg/mL against B. subtilis, M. luteus, E. faecalis and E. coli, respectively. The cinachyramides caused morphological changes in B. subtillis and E. coli. The scanning electron microscopy (SEM) analysis suggests formation of protuberances and permeabilization of membranes, which might generate bacterial lysis with loss of cytoplasmic components and reduction in bacterial size. The antibacterial action can be associated to the electrical charges on the cinachyramides being more sensitive the Gram positive bacteria. The antibacterial power of the mixture of cinachyramides is similar to that of the penicillin G sodium salt. The organic fraction from the hydrolyzate of the mixture of cinachyramides was found to consist of an acyl residue derived from: decanoic, tridecanoic, pentadecanoic, hexadecanoic, octadecanoic or 9-Z-octadecenoic while the polyaminic part was composed of up to 12 repeated units of N-methylated propylamine. © 2015, Interamerican Society for Electron Microscopy (CIASEM). All rights reserved.

Susana P.G.,National Autonomous University of Mexico | Aarland R.C.,Metropolitan Autonomous University | Lara M.G.C.,Centro Medico Nacional Hospital Siglo XXI | Jimenez Lara M.E.,National Autonomous University of Mexico | Jose Alberto M.E.,Laboratorio Of Productos Naturales
Asian Journal of Plant Sciences | Year: 2013

The Mora herb is an herbaceous plant that is frequently employed in the periphery of the Santa Catarina mountains, Mexico. In the present research, the Mora herb was typified as two different species that belong to the same gender, Solanum nigrescens Mart, and Gal. and Solanum cervantesii Lag. Extracts from the aerial part of the species were obtained by direct maceration using hexane, ethyl acetate and methanol. Phytochemical and pharmacologic studies were carried out afterwards. These studies found that the species have different pharmacological and chemical patterns in the studied experimental models and therefore, determined that they might possess different medical properties, thus explaining the wide variety of therapeutic qualities that had been attributed to the Mora herb. This indicates the need to carry out a study that revises the pharmacological properties of this plant, placing an emphasis on identifying the specie. © 2013 Asian Network for Scientific Information.

Nieves E.,University of Los Andes, Venezuela | Mendez J.F.,University of Los Andes, Venezuela | Lias J.,Laboratorio Of Productos Naturales | Rondon M.,University of Los Andes, Venezuela | Briceno B.,University of Los Andes, Venezuela
Revista de Biologia Tropical | Year: 2010

Repellent activity of plant essential oils against bites of Lutzomyia migonei (Diptera: Psychodidae). Natural repellents from plant extracts have demonstrated good efficacy against bites of some insect species. The present study evaluated the repellent effect of essential oils extracted from 8 plants species against bites of Lutzomyia migonei, the Leishmania vector. The essential oils were extracted by steam destillation in Clevenger chamber, from the following plants: Hyptis suaveolens, Pimenta racemosa, Piper marginatum, Monticalia imbricatifolia, Pseudognaphalium caeruleocanum, Espeletia shultzii, Plecthranthus amboinicus and Cinnamomun zeylanicum. Repellency tests were performed under laboratory conditions by the human hand method in cage assays, using female colonies of L. migonei. The more effective oils were tested at variable concentrations on different volunteers. The protection percentage and time were calculated. The results showed what oils of P. caeruleocanum and C. zeylanicum were the most effective. Although P. amboinicus oil also had repellent effect showed an irritant effect. The oils P. marginatum, H. suaveolens and P. racemosa showed no repellent effect, while the rest of oil extracts showed significant repellency in variable degrees. P. caeruleocanum and C. zeylanicum oils provided the 95% protection against bites of L. migonei for 3h. The P. caeruleocanum oil showed the greatest protection time, with a mean over 4h and 3h at concentrations of 50% and 10% respectively. The results suggest that the P. caeruleocanum oil could represent a potential natural repellent against Leishmania vectors.

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