Entity

Time filter

Source Type


Velasquez-Jones L.,Hospital Infantil de Mexico Federico Gomez | Medeiros M.,Laboratorio Of Investigacion En Nefrologia Y Metabolismo Mineral Oseo | Valverde-Rosas S.,Hospital Infantil de Mexico Federico Gomez | Jimenez-Triana C.,Hospital Infantil de Mexico Federico Gomez | And 3 more authors.
Boletin Medico del Hospital Infantil de Mexico | Year: 2015

Vitamin D dependent rickets type I is a rare hereditary disease due to a mutation in CYP27B1 encoding the 1α-hydroxylase gene. Clinically, the condition is characterized by hypocalcemic rickets in early infancy due to a deficit in the production of the vitamin D active metabolite 1,25-dihydroxy-vitamin D3. Case report: We report the case of a patient diagnosed at 11 months with follow-up until 9 years of age. Conclusions: The pathophysiology of the disease and the relevance of early diagnosis and management are discussed. © 2015. Source


De Jesus Coria-Lorenzo J.,Ensenanza e Investigacion | Sotelo-Cruz N.,University of Sonora | Ramirez-Bouchand D.,Hospital del Nino y la Mujer de San Luis Potosi | Enriquez-Cisneros O.,Hospital General de Occidente | And 9 more authors.
Revista Mexicana de Pediatria | Year: 2015

Introduction: The Kawasaki disease is an acute systemic inflammatory disease, being responsible for the most frequent cause of acquired heart disease and aneurysms in children. Its evolution includes three clinical stages (acute, sub-acute and convalescence). Material and methods: We conducted a multicenter, descriptive analysis; simple and accumulated frequencies were calculated, as well as percentages. This study included nine hospitals to know the clinical and epidemiological characteristics of the disease in Mexican children. Results: Of 182 files reviewed, three were eliminated by lacking echocardiogram, remaining 179; from those, 16 cases did not have any kind of rash at any time of the disease. Four corresponded to a classic or complete Kawasaki and twelve to the incomplete form. The age was between five months to 22 years, being 44% female and 56% male. The evolution of the disease at the time of diagnosis was on average of 10 days with a range of 5-22 and media of 9 days. There were nine cases with coronary aneurysm, 8 of them were incomplete, and 5 of these had a low platelet count. Analysis: With regard to diagnosis of Kawasaki disease according to major clinical criteria in addition to the fever, patients with 3 and 2 criteria were the most relevant, 37 and 31%, respectively; followed by those who showed 4 criteria (25%); and only one patient with a single criterion. Conclusions: The patients with unexplained fever, high acute-phase reactants and conjunctivitis should alert the physician to suspect KD even if they do not show any rash. Source


Toussaint-Martinez de Castro G.,Laboratorio Of Investigacion En Nefrologia Y Metabolismo Mineral Oseo | Kaufer-Horwitz M.,Conducta | Carrillo-Lopez H.A.,Hospital Infantil de Mexico Federico Gomez | Klunder-Klunder M.,Hospital Infantil de Mexico Federico Gomez | And 2 more authors.
Boletin Medico del Hospital Infantil de Mexico | Year: 2013

Background. In Mexico the epidemiology of the nutritional status of pediatric patients has changed. Currently, nutritional diseases are better appreciated when patients are admitted to the pediatric intensive care units. Methods. A retrospective study was conducted from November 2002 to December 2007 in the Pediatric Intensive Care Unit (PICU) at the Hospital Infantil de México Federico Gómez. We recorded anthropometric data of children upon admission to the PICU. Nutritional status was calculated according to Z-score of body mass index in children <2 years of age according to the World Health Organization and in children 2-18 years of age according to the Centers for Disease Control and Prevention. Results. Prevalence of malnutrition, risk of malnutrition, overweight and obesity for children <2 years of age was 36.2%, 24.1%, 4.6% y 4.9%, respectively, and for preschool-age children was 24.2%, 22.1%, 9.2% and 7.6%, respectively. For school-age children, the percentages were 16.1% for malnutrition, 16.8% risk for malnutrition, 16.1% overweight, and 5.8% for obesity. In adolescents these values were 16.2%, 16.9%, 15.6% and 2.1%, respectively, for malnutrition, risk of malnutrition, overweight and obesity. Conclusions. Risk for diseases such as malnutrition continues to be present in children admitted to pediatric intensive care units. However, other emerging diseases such as overweight and obesity have a high frequency. This shows that the epidemiological situation of children with serious illnesses is not very different from the general population. Source


Guadarrama-Diaz E.O.,Hospital Infantil de Mexico Federico Gomez | Garcia-Roca M.I.P.,Laboratorio Of Investigacion En Nefrologia Y Metabolismo Mineral Oseo | Reyes-Perez H.,Laboratorio Central | Medeiros M.,Hospital Infantil de Mexico Federico Gomez | Medeiros M.,Laboratorio Of Investigacion En Nefrologia Y Metabolismo Mineral Oseo
Boletin Medico del Hospital Infantil de Mexico | Year: 2013

Background. Tacrolimus is a widely used immunosuppressant in renal transplant patients. Drug monitoring is performed by measuring trough levels. Pharmacodynamic monitoring is used to evaluate the biological effect. The aim of the study was to determine the relationship between tacrolimus area-under concentration vs. time curve (AUC) and the gene expression of tumor necrosis factor alpha (TNF-α) in children with renal transplant. Methods. An experimental, cross-sectional study was performed in children with renal transplant at 3 months after transplant. An 8-h pharmacokinetic-pharmacodynamic profile was obtained. Gene expression of TNF-α and internal control of 18s rRNA was performed by real-time PCR. CYP3A5 genotype was obtained by direct sequencing. Results. Six patients were included with a median age of 14.5 years. A negative correlation was found between tacrolimus pharmacokinetics and TNF-α gene expression. There was a trend of low TNF-α with high tacrolimus blood levels. Conclusions. There is a negative correlation between tacrolimus concentration and TNF-α gene expression. TNF-α gene expression was not modified by CYP3A5 genotype. Source


Navarrete-Rodriguez E.M.,Servicio de Alergia e Inmunologia Clinica Pediatrica | Del Rio-Navarro B.E.,Servicio de Alergia e Inmunologia Clinica Pediatrica | Garcia-Aranda J.A.,Direccion General | Medeiros M.,Laboratorio Of Investigacion En Nefrologia Y Metabolismo Mineral Oseo | And 3 more authors.
Boletin Medico del Hospital Infantil de Mexico | Year: 2015

Background: The backbone of food allergy treatment is the restriction of causative foods. These interventions have shown that children who restrict the consumption of basic foods have a higher risk of malnutrition.The aim of the study was to identify the nutritional status of patients with elimination diet, characterizing their anthropometric indexes and identifying the percentage of patients in the group with true food allergies. Methods: A cross-sectional study was carried out from January to October 2014 at the Hospital Infantil de Mexico Federico Gomez. Patients 1 to 11 years of age with a history of elimination of at least one of five foods (eggs, milk, wheat, corn, soybeans) for a minimum of 6 months were included. Full nutritional assessment was performed by comparing the anthropometric indexes to z score for age. Data analysis used descriptive statistics. Kruskal-Wallis and Spearman correlation were performed. Results: The most frequent eliminated foods were milk, soy, eggs, corn, and wheat. Comparing the number of foods eliminated with different anthropometric indexes, with a greater amount of eliminated food, the z-score of weight/age (W/A), height/age (H/A) and weight/height (W/H) were lower and the most affected index was fat reserve. Only in 5% of children was food allergy confirmed. Conclusions: The study confirms the need for nutrition counseling for patients who have elimination diets and overdiagnosis of food allergy. © 2015. Source

Discover hidden collaborations