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Mexico City, Mexico

Moreno-Eutimio M.A.,Laboratorio Of Inmunobiologia | Moreno-Eutimio M.A.,National Polytechnic Institute of Mexico | Acosta-Altamirano G.,National Polytechnic Institute of Mexico
Cirugia y Cirujanos | Year: 2014

Sedentary lifestyle leads to the accumulation of visceral fat. This is accompanied by the infiltration of immune cells with pro-inflammatory characteristics in adipose tissue, causing an increased release of cytokines and generating a low-grade inflammatory state. It has been associated with the development of insulin resistance, atherosclerosis, neurodegeneration, and development of tumors. Exercise can be used as a treatment to improve symptoms of many of these conditions because it promotes an anti-inflammatory effect. In this review we analyze the pro-inflammatory factors present in obesity and the induction of antiinflammatory factors that occur with exercise. Source

Partida-Perez M.,Institute Genetica Humana | De La Luz Ayala-Madrigal M.,Institute Genetica Humana | Peregrina-Sandoval J.,Laboratorio Of Inmunobiologia | MacIas-Gomez N.,Laboratorio Of Genetica Humana | And 7 more authors.
Cancer Biomarkers | Year: 2010

Leptin and adiponectin are cytokines produced by adipose tissue with opposite effects on tumor growth: the former stimulate whereas the latter inhibit it. The objective was to analyze the association of LEP A19G and ADIPOQ+45 T/G and +276 G/T polymorphisms in Mexican patients with colorectal cancer (CRC). 68 unrelated patients with CRC (study group) and 102 blood donors (control group); all subjects were Mestizos from western Mexico. The polymorphisms were established by PCR-RFLP on DNA samples obtained from peripheral blood. The LEP A19G polymorphism showed significant differences between CRC patients and control group (p= 0.01 for G/A genotype and p= 0.02 for the recessive model G/G +G/A); yet, in the analysis stratified by gender, this difference remained significant only in males. The ADIPOQ polymorphisms did not shown any significant differences. Our results suggest that the A19G LEP polymorphism is associated with CRC in Mexican patients. © 2010-IOS Press and the authors. All rights reserved. Source

Vargas-Hernandez V.M.,Direccion de Investigacion | Garcia-Rodriguez F.M.,Servicio de Oncologia | Jimenez-Villanueva X.,Servicio de Oncologia | Hernandez-Rubio A.,Servicio de Oncologia | And 2 more authors.
Cirugia y Cirujanos | Year: 2013

Introduction: Breast cancer is diagnosed in pregnant women during pregnancy or the first year after childbirth, and is the second leading cause of death among women of reproductive age. In the Juarez Hospital of Mexico are unknown frequency of this disease and the characteristics of the women affected. This paper analyzed the cases of pregnant women diagnosed with breast cancer, treated the Oncology Department over a period of 10 years (1990-2000). Methods: We performed a retrospective descriptive study of pregnant women diagnosed with breast cancer, treated at. Of the cases found, the following indicators were studied: maternal age, type of cancer, and weeks of gestation at the time of diagnosis, resolution of pregnancy and perinatal outcome, and treatment monitoring. Descriptive statistics were performed using measures of central tendency and dispersion. Results: There were 14 cases of pregnant women with breast cancer. The mean age of patients was 28 years, with a mean of 23 weeks gestation at diagnosis. The resolution of pregnancy was favorable in 73% of cases. The 78.6% of the patients were treated, 72.7% had follow-up for 2 years, found 62.5% of patients without tumor activity. Conclusions: The frequency of pregnant women with breast cancer is low, affecting young people. The choice of treatment allowed the resolution of pregnancy and survival of women without tumor activity. Source

Acosta-Altamirano G.,Direccion de Investigacion | Moreno-Eutimio M.A.,Laboratorio Of Inmunobiologia | Vargas-Aguilar V.M.,Direccion de Investigacion
Cirugia y Cirujanos | Year: 2014

Cancer screening programs have been successful in reducing the incidence and mortality due to cervical cancer. For more than a decade, the human papillomavirus test has been recommended as part of these programs, however, Pap tests is not currently recommended for women <21 years of age or in those with total hysterectomy for benign disease, unrelated to cancer or precursor lesions of malignant diseases. This is because most of the anomalies observed in adolescents regress spontaneously, and cytological screening tests for this age group cause unnecessary anxiety, additional testing and, therefore, a higher cost. Moreover, there is little evidence that cytology is useful in women after hysterectomy, finding that outcomes are not improved. In women >65 years of age who participated adequately in screening programs, continuing with these screening programs is not needed. Screening programs will be different in special populations at greatest risk where tests are frequently needed or use of alternative methods. Source

Moreno-Eutimio M.A.,Mexican Social Security Institute IMSS | Moreno-Eutimio M.A.,Laboratorio Of Inmunobiologia | Tenorio-Calvo A.,Mexican Social Security Institute IMSS | Pastelin-Palacios R.,National Autonomous University of Mexico | And 10 more authors.
Immunology | Year: 2013

Salmonella enterica serovar Typhi (S. Typhi) is the causal agent of typhoid fever, a disease that primarily affects developing countries. Various antigens from this bacterium have been reported to be targets of the immune response. Recently, the S. Typhi genome has been shown to encode two porins - OmpS1 and OmpS2 - which are expressed at low levels under in vitro culture conditions. In this study, we demonstrate that immunizing mice with either OmpS1 or OmpS2 induced production of specific, long-term antibody titres and conferred protection against S. Typhi challenge; in particular, OmpS1 was more immunogenic and conferred greater protective effects than OmpS2. We also found that OmpS1 is a Toll-like receptor 4 (TLR4) agonist, whereas OmpS2 is a TLR2 and TLR4 agonist. Both porins induced the production of tumour necrosis factor and interleukin-6, and OmpS2 was also able to induce interleukin-10 production. Furthermore, OmpS1 induced the over-expression of MHC II molecules in dendritic cells and OmpS2 induced the over-expression of CD40 molecules in macrophages and dendritic cells. Co-immunization of OmpS1 or OmpS2 with ovalbumin (OVA) increased anti-OVA antibody titres, the duration and isotype diversity of the OVA-specific antibody response, and the proliferation of T lymphocytes. These porins also had adjuvant effects on the antibody response when co-immunized with either the Vi capsular antigen from S. Typhi or inactivated 2009 pandemic influenza A(H1N1) virus [A(H1N1)pdm09]. Taken together, the data indicate that OmpS1 and OmpS2, despite being expressed at low levels under in vitro culture conditions, are potent protective immunogens with intrinsic adjuvant properties. © 2013 John Wiley & Sons Ltd. Source

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