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Acosta de la Luz C.L.L.,Laboratorio Central Of Farmacologia
Revista Cubana de Plantas Medicinales

Introduction: growing medicinal species in containers is a beneficial practice permitting the profitable utilization of small household areas, such as balconies, roofs and terraces, which will look better if a touch of gardening is added. Objectives: in view of the growing demand for medicinal plants, a workshop was conducted in the municipality of Old Havana (Havana Pharmacy Museum) to be attended by gardeners and housewives from the community, to discuss the advantages of this form of plant cultivation. Methods: the topics dealt with included general knowledge about the cultivation of various species based on their characteristics and demand, the use of a variety of containers depending on the area available, the substratum to be used, the best use of light, watering and fertilization requirements, and the problems that may arise and how to solve them. Results: analysis of some selected plants showed that this activity may facilitate lifestyle change by providing easy access to a variety of species serving many different purposes, not only medicinal, but also as spices to be used either fresh or dry to flavor food, and for ornamental purposes. Her freces which could be erent purposes, not. Conclusions: household economy may be improved with the consumption of spices, vegetables, medicinal plants and other crops grown in small containers. These contribute to the preservation of health by constituting a home pharmacy providing phytomedicines for the treatment of common diseases. Source

Suarez H.C.,Laboratorio Central Of Farmacologia | Figueredo Y.N.,Research Center sarrollo Of Medicamentos
Revista Cubana de Plantas Medicinales

INTRODUCTION: Pedilanthus tithymaloides (L.) Poit. (known as ítamo real) is a widely distributed plant in Cuba and at the same time a sustainable source of active principles. OBJECTIVE: to evaluate the neurosedative effect of cycloartanol triterpene from dichlorometane extract obtained from Pedilanthus tithymaloides (L.) Poit. leaves. METHODS: models based on exploratory behaviour, barbiturate-induced sleep, pentilenotetrazol-induced seizures and amphetamine-induced stereotyped behaviours were used. Cyclocartanol was orally administered 30 minutes before every test. RESULTS: exploratory behaviour was inhibited at over 50 mg/kg dose; amphetamine-induced stereotyped behaviours were inhibited at 200 mg/kg dose; thiopental-induced sleep was potentiated at over 50 mg/kg dose, however, protection against pentilenotetrazole-induced seizures was not observed. CONCLUSIONS: the results of several tests indicate a depressing effect on the central nervous system of laboratory animal treated with Cycloartanal; however, the sedative effect does not seem to be mediated by the GABAergic system. Antidepressive effects were not observed either. Source

INTRODUCTION: the dissemination of information about "fantastic" remedies to cure diseases feared by everybody because of their possible fatal outcome, or those "cure all" substances that may solve more than one hundred health problems is unfortunately frequent on Internet and creates false expectations in patients, relatives and even health professionals. There are some pieces of information on the Web that Annona muricata L. is able to cure cancer. OBJECTIVES: to determine if there is published scientific information that allows validating the use of this plant in the treatment of cancer. METHODS: the main scientific biomedical literature databases available (BVSBIREME /11/, COCHRANE /0/, PubMed /5/, LILACS /2/, SciELO /0/, SeCiMed /0/, EBSCO /2) were reviewed, using key words as Annona AND muricata AND cancer. Likewise, review was made in Google using graviola and cancer. The obtained information was then analyzed to ascertain whether it can substantiate the abovementioned recommendation. RESULTS: it was found that the published scientific studies that might substantiate the use of this plant or some of its extracts are based on in vitro experimental models and most of them used pure extracted active principles. CONCLUSIONS: there is not enough evidence to recommend the use of any extract or active principle from A. muricata, so the groundless publication of its "extraordinary anti-cancer properties" is unacceptable from the ethical viewpoint. Source

Perez Machin M.,University of Medical Sciences of Costa Rica | Sueiro Oyarzun M.L.,University "Marta Abreu" of Las Villas | Boffill Cardenas M.D.L.A.,University of Medical Sciences of Costa Rica | Moron Rodriguez F.,Laboratorio Central Of Farmacologia | And 3 more authors.
Boletin Latinoamericano y del Caribe de Plantas Medicinales y Aromaticas

An ethnobotanic study was carried out combining methods and techniques characteristic of the qualitative and quantitative investigation, in 10 municipalities of Villa Clara province, Cuba. It was taken a heterogeneous sample of 250 people constituted for: experts of plants, herbalists and expert doctors in phytotherapy who identified the plants more used with these ends in the studied communities. The data obtained starting from the consent of informants, were analyzed by means of the index of use value (IVU) and the level of significant use (UST) of the Tradicional of the Medicine of the Island (TRAMIL). They registered 20 medicinal species contained in 14 botanical families and they met 8 plants with a bigger use level and a bigger IVU. 60% of the plants reported as diuretic lacked scientific validation, the rest of the identified species has been studied at preclinic level, although in its great majority they don't appear in the Cuban Pharmacopeia of Medicinal Plants neither they are authorized by the agency Cuban reguladora, Center for the State Control of the Quality of the Medications (CECMED). The documentation related with the uses of the medicinal plants in the study areas, reveal that the traditional knowledge continues deeply ingrained to the communities and the popular knowledge stays in the representative figures of the herbalists and the experts of plants. The present work intends to evaluate through the medical ethnobotany, the current state of the traditional knowledge on medicinal plants with diuretic activity attributed in several communities of Villa Clara province, Cuba. © 2011 The Authors. Source

del Carmen Victoria Amador M.,Laboratorio Central Of Farmacologia | Rodriguez F.J.M.,Laboratorio Central Of Farmacologia
Revista Cubana de Plantas Medicinales

INTRODUCTION: bioethics in research involving laboratory animals has shown important advances in Cuba and worldwide. OBJECTIVES: to update information about the research ethics involving animals and its development in Cuba and in research laboratory setting. METHODS: The main scientific biomedical literature database available and also Google were reviewed (BVS-BIREME, PubMed, LILACS, SciELO, EBSCO) using key words bioethics, animals and experimental. The obtained information was analyzed to ascertain whether it could be used for the present paper. RESULTS: the concepts of ethics and bioethics, the use of animals as source of knowledge and biological models were reviewed. The importance of health control, the barriers, genetics and the production in certified centers, the environmental conditions of breeding and experimentation were stated; the bioters and the advantages of the most used species were characterized; the importance of alternative methods as the 3R principle (replacement, reduction and refining) as well as the ethical considerations that one must take into account since they are alive were also pointed out. The present situation in Europe, North America, Latin America and Cuba- where the National Center for the Production of Laboratory Animals is the leading center of lab animal production- was assessed. The Central Laboratory of Pharmacology, its objectives, the techniques and animal species used there were described. A comparison was made between the number of animals used in the past and at present. CONCLUSIONS: the implementation of bioethical principles of lab animal experimentation is a priority in Cuba. Source

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