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Eleuteri E.,Laboratorio Of Citoimmunopatologia Apparato Cardio Respiratorio Fondazione Salvatore Maugeri | Di Stefano A.,Laboratorio Of Citoimmunopatologia Apparato Cardio Respiratorio Fondazione Salvatore Maugeri | Vallese D.,Laboratorio Of Citoimmunopatologia Apparato Cardio Respiratorio Fondazione Salvatore Maugeri | Gnemmi I.,Laboratorio Of Citoimmunopatologia Apparato Cardio Respiratorio Fondazione Salvatore Maugeri | And 7 more authors.
Biomarkers | Year: 2014

Background: Fibrosis suppressors/activators in chronic heart failure (CHF) is a topic of investigation. Aim: To quantify serum levels of fibrosis regulators in CHF. Methods: ELISA tests were used to quantify fibrosis regulators, procollagen type-(PIP)I, (PIP)III, collagen-I, III, BMP1,2,3,7, SDF1α, CXCR4, fibulin 1,2,3, BMPER, CRIM1 and BAMBI in 66 CHF (NYHA class I, n=9; II, n=34; III n=23), and in 14 controls. Results: In CHF, TGFβR2, PIPIII, SDF1α and CRIM1 were increased. PIPIII correlated with CRIM1. Conclusions: The BMPs inhibitor CRIM1 is increased and correlates with higher levels of serum PIPIII showing an imbalance in favor of pro-fibrotic mechanisms in CHF. © 2014 Informa UK Ltd. All rights reserved: reproduction in whole or part not permitted. Source

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