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Votto A.P.S.,Grande Rio University | Domingues B.S.,Grande Rio University | de Souza M.M.,Laboratorio Of Ciencia Of Alimentos | da Silva Junior F.M.R.,Pos graduacao em Ciencias Fisiologicas | And 7 more authors.
Biological Research

Onion (Allium cepa) is being studied as a potential anticancer agent, but little is known regarding its effect in multidrug resistance (MDR) cells. In this work, the cytotoxicity of crude onion extract (OE) and fractioned extract (aqueous, methanolic and ethyl acetate), as well as some onion compounds (quercetin and propyl disulfide) were evaluated in Lucena MDR human erythroleukemic and its K562 parental cell line. The capacity of OE to induce apoptosis and/or necrosis in these cells, the possible participation of oxidative stress and DNA damage were also assessed. Similar sensitivities were obtained for both tumoral cells, however only OE caused significant effects in the cells. In K562 cells, a significant increase of apoptosis was verified while the Lucena cells experienced a significant increase of necrosis. An antioxidant capacity was verified for OE discarding oxidative damage. However, OE provoked similar significant DNA damage in both cell lines. Thus, the OE capacity to overcome the MDR phenotype suggests anti-MDR action of OE. Source

Rodrigues J.S.Q.,University of Brasilia | Pineli L.L.O.,University of Brasilia | Rodrigues N.G.,Catholic University of Brasilia | De Lima H.C.,Laboratorio Of Ciencia Of Alimentos | And 4 more authors.
Revista Ceres

The objective of this study was to evaluate the sensory profile and acceptability of passion fruit nectar obtained from plants cultivated under different production systems: organic or conventional, with or without shading by intercropping with cassava. The samples were evaluated by Quantitative Descriptive Analysis and Acceptance Testing with hedonic scale. Data from the descriptive profile and acceptance were analyzed by External Preference Mapping, Analysis of Variance and the Fisher's LDS test. Fruits that were not subjected to shading produced nectars with very similar sensory profile and greater acceptance. Unshaded conventional and unshaded organic passion fruit nectars correlated with the attributes "green aroma", "homogeneity" and "sour taste". The greatest differences in acceptance were found between shaded conventional and unshaded organic samples for the attributes of color, flavor and overall quality. External preference mapping showed that the sample of nectar from shaded conventional passion fruit, with lower acceptance, was correlated with the attributes fibrousness and viscosity. Source

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