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Puebla de Zaragoza, Mexico

Reyes-Lazalde A.,Laboratorio Of Biologia Interactiva | Reyes-Monreal M.,Direccion General de Innovacion Educativa | Perez-Bonilla M.E.,Laboratorio Of Biologia Interactiva | Reyes-Luna R.,Laboratorio Of Biologia Interactiva
Revista Mexicana de Ingenieria Biomedica

In intensive care units, one of the most frequent emergencies occurring in patients in critical condition is acid-base imbalance. The ability to proficiently manage such patients is achieved through many years of hospital practice. The correct quantification of such imbalances allows for the detection of complex alterations. Although this area is fundamental for the clinical management of many patients, nonspecialist doctors rarely receive the appropriate training. In addition, the learning required to master this area is difficult for doctors due to the level of mathematics involved. There are two online support programs available on the internet for determining blood pH based on the Stewart Model, along with a spreadsheet for the patient's collected data. Generally, the calculation of hydrogen ion concentration [H+] uses a table of equivalences between pH y [H+] for discontinuous values of pH, with the Davenport diagram used manually. However, none of these programs unite the methods of classic calculus, chemistry and physicochemistry. This study develops software for the teaching and calculation of acid-base imbalance that combines all the relevant methods, such as the Henderson-Hasselbalch equation, the Siggard- Anderson modified excess base equation, the anion gap calculation, the computational implementation of the Davenport diagram, the calculus of [H+] for any value of pH, the calculus for the compensatory process, and the Stewart Model. The combined use of these methods is complementary, synergic and permits a preliminary diagnosis that interprets and understands both respiratory alterations and miniscule metabolic or mixed alterations. With this software, a doctor can identify acid-base imbalances and the occurrence of compensatory processes, such as the concentration of acid or base, in order to restore pH, while many simulations of clinical cases can be carried out in the classroom for medical training purposes. © Revista Mexicana de Ingeniería Biomédica. Source

Lazalde A.R.,Laboratorio Of Biologia Interactiva | Perez Bonilla M.E.,Laboratorio Of Biologia Interactiva | Monreal M.R.,Maestria en Estetica
Revista Mexicana de Ingenieria Biomedica

In recent years, interactive media and tools, such as scientific simulators and simulation environments or dynamic data visualizations, have became established methods in the neural, medical, physiological and biophysical sciences. This article presents two simulators designed and developed for the study of the passive properties of the axon and dendritic tree: HR2 and Rall1. The HR2 is an interactive program that reproduces the classic experiments of Hodgkin and Rushton (1946)1 to determine the electrical constants of a crustacean nerve fiber. Rall1 is an interactive program that enables the study of the Rall model by reducing the dendritic tree to an electrically equivalent cylinder2. With these simulators, students can determine the time constant and electrotonic length in axons and dendrites. These simulators are powerful tools for exploring and analyzing the complexity of the passive properties in neural information processing. Source

Reyes-Lazalde A.,Laboratorio Of Biologia Interactiva | Reyes-Monreal M.,Innovacion Educativa | Perez-Bonilla M.E.,Laboratorio Of Biologia Interactiva
Revista Mexicana de Ingenieria Biomedica

Hodgkin and Huxley's works were the starting point to generating mathematical models for explain, reproduce the experimental results and predict the behavior of voltage-sensitive ion channels in the axon. The high costs of these experiments avoid its implementation in teaching degree. An educational alternative is virtual experiments using computer simulations. In this work the development of a simulator that reproduces step by step the classic experiments of Hodgkin and Huxley on the conductance of voltage-dependent channels in squid giant axon is presented. The simulator was developed in Visual Basic language, ver 5.0 for Windows environment. It consists of four modules: (1) ionic currents simulation; (2) classical Hodgkin and Huxley's experiments; (3) current version model; (4) action potentials. It comprises connecting interface screens that allow simulate and compute the values of the variables associated with the channel conductance. The user can perform an unlimited number of virtual experiments that will facilitate the understanding of the subject. Source

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