Lima J.G.B.,Laboratorio Of Patologia E Biointervencao |
de Freitas Vinhas C.,Laboratorio Of Patologia E Biointervencao |
Gomes I.N.,Laboratorio Of Patologia E Biointervencao |
Azevedo C.M.,Laboratorio Of Engineering Tecidual E Imunofarmacologia |
And 3 more authors.
Biochemical and Biophysical Research Communications | Year: 2011
Recent studies have demonstrated that communication takes place between the autophagic and phagocytic pathways, indicating that the convergence of these two pathways plays an important role in the innate immune response against intracellular microbes. The present study investigated the effect of autophagic induction on the phagocytic capacity of murine macrophages. Autophagy induced by physiological and pharmacological means was shown to reduce the phagocytic capacity of murine macrophages, regardless of cell origin or the nature of the phagocytosed particles themselves. This autophagic inhibitory effect on phagocytosis was shown to be an early and reversible event that results in no loss of cell viability. Furthermore, the data presented herein demonstrate that the induction of autophagy does not affect a macrophage's capacity to recognize and bind to particles, indicating that autophagy does not inhibit the particle recognition process, even though particle internalization is suppressed. The findings herein support the notion that phagocytosis and autophagy may be interdependent and complementary processes. © 2011 Elsevier Inc. Source