Santa Fe de la Vera Cruz, Argentina
Santa Fe de la Vera Cruz, Argentina

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Brance M.L.,Hospital Provincial del Centenario | Brance M.L.,Laboratorio Of Biologia Osea | Brance M.L.,CONICET | Brun L.R.,Laboratorio Of Biologia Osea | And 4 more authors.
Rheumatology International | Year: 2015

Rheumatoid arthritis (RA) is a chronic systemic inflammatory autoimmune disease with high prevalence of osteoporosis. Previous evidence indicates an association between vitamin D deficiency and autoimmune diseases. The aim of this study was to evaluate serum 25 hydroxyvitamin D [25(OH)D] levels, bone mineral density (BMD) and disease activity in RA patients living in Argentina. We studied 34 RA women and 41 healthy women as a control group. RA patients had lower 25(OH)D levels (20.4 ± 0.9 ng/ml) than controls (26.3 ± 1.9 ng/ml; p < 0.05). No significant differences were found in lumbar spine BMD between premenopausal (preM) or postmenopausal (postM) patients, but femoral neck BMD was significantly lower in postM RA patients (T score −2.5 ± 0.4) than in postM control subjects (T score −0.9 ± 0.3, p = 0.014). Although no linear correlation between 25(OH)D levels and disease activity (DAS-28) was found, patients with moderate-high disease activity had lower 25(OH)D levels than those with low disease activity: DAS-28 >3.2: 19.5 ± 0.88 ng/ml; DAS-28 ≤3.2: 23.7 ± 2.8 ng/ml (p = 0.047). After 1 year of vitamin D treatment 25(OH)D levels were increased while DAS-28 were decreased (n = 25; p < 0.05). We conclude that patients with RA had lower 25(OH)D levels than the control group. Low levels of 25(OH)D were associated with moderate-high disease activity suggesting the importance of optimal 25(OH)D levels in RA patients. Femoral neck BMD was lower in postM RA patients. No differences in lumbar BMD were found between preM and postM RA patients, suggesting that bone mass evaluation in RA patients should include femoral neck BMD regardless of age. © 2014, Springer-Verlag Berlin Heidelberg.


Lupo M.,Laboratorio Of Biologia Osea | Lupo M.,National University of Rosario | Fina B.L.,Laboratorio Of Biologia Osea | Fina B.L.,National University of Rosario | And 6 more authors.
Water, Air, and Soil Pollution | Year: 2012

The upper limit of fluoride concentration in water for human consumption is 1.5 ppm.Many studies have been carried out concerning the water fluoride concentration in wide areas around the world, but none have studied the change of fluoride concentration as a function of geographical coordinates and through time. This paper describes 'microvariation' of fluoride concentration among wells separated by less than 500 m in a month. On the other hand, 'macrovariation' is also studied describing changes among cities that are separated by more than 10 km and compared with fluoride concentrationsmeasured 65 years ago. Fluoride concentration was measured in a wide geographical area of Argentina, which is 133,000 km 2. Samples of water were collected from different regions. Macrovariation: Differences in fluoride concentration in well water among regions were found, as well as an increase in water fluoride concentration during seven decades. Microvariation: Daily water fluoride concentration in a specific area displayed a great variation in the measurements through time. In addition, wells with no more than 500 m of separation were measured at the same time and were significantly different. These results indicate that in order to determine the fluoride concentration of a region, different samples of the same area should be obtained and a sampling through time should also be done. © Springer Science+Business Media B.V. 2012.


Bibliometrics is a set of methods used to study or measure texts and information. While bibliometric methods are most often used in the field of library and information science, bibliometrics variables have wide applications in other areas. One popular bibliometric variable is Garfield's Impact Factor (IF). IF is used to explore the impact of a given field, the impact of a set of researchers, or the impact of a particular paper. This variable is used to assess academic output and it is believed to affect adversely the traditional approach and assessment of scientific research. In our country, the members of the evaluation committees of intensive research institutions, e.g. the National Scientific and Technical Research Council (CONICET) use IF to assess the quality of research. This article revises the exponential growth of bibliometrics and attempts to expose the overall dissatisfaction with the analytical quality of IF. Such dissatisfaction is expressed in the number of investigations attempting to obtain a better variable of improved analytical quality.


PubMed | Laboratorio Of Biologia Osea
Type: Journal Article | Journal: Medicina | Year: 2011

Bibliometrics is a set of methods used to study or measure texts and information. While bibliometric methods are most often used in the field of library and information science, bibliometrics variables have wide applications in other areas. One popular bibliometric variable is Garfields Impact Factor (IF). IF is used to explore the impact of a given field, the impact of a set of researchers, or the impact of a particular paper. This variable is used to assess academic output and it is believed to affect adversely the traditional approach and assessment of scientific research. In our country, the members of the evaluation committees of intensive research institutions, e.g. the National Scientific and Technical Research Council (CONICET) use IF to assess the quality of research. This article revises the exponential growth of bibliometrics and attempts to expose the overall dissatisfaction with the analytical quality of IF. Such dissatisfaction is expressed in the number of investigations attempting to obtain a better variable of improved analytical quality.

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