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Buenos Aires, Argentina

Garcia M.G.,Laboratorio MANLAB | Bolontrade A.J.,Laboratorio Bolontrade | Penacino G.A.,Colegio Oficial de Farmaceuticos y Bioquimicos | Chiesa I.J.,Laboratorio MANLAB | Perez M.S.,Laboratorio MANLAB
Forensic Science International: Genetics Supplement Series

A marked increase in multiple pregnancies has been observed in recent years, this suggests an increase of twin brothers involved in paternity cases. Occasionally, it has been seen in many court cases involving twins' participation, the attempt to prove that tested paternity to the alleged father for one of them, necessarily implies the same result for the other.This article describes a rare event called heteropaternal superfecundation (HS) detected in a case of paternity investigation which involves a set of twins conducted in our laboratory.The probability of paternity (PP) of twin 2 was 99.999% and the combined paternity index (CPI) obtained was 1×107. Whereas that for twin 1 was excluded in 14 out of 17 Y-chromosome DNA markers and in 11 out of 15 autosomal short tandem repeats (STR) markers tested.Although the frequency of these events is not high, its likelihood is possible, as showed in this study. Therefore, assuming that sometimes it is intended that the same result can be shared by two brothers, by the mere fact of being twins would have meant a great negligence. © 2015 Elsevier Ireland Ltd. Source

Chiesa I.J.,Laboratorio MANLAB | Serafino J.J.,Laboratorio MANLAB | Garcia M.G.,Laboratorio MANLAB | Nunez G.G.,Laboratorio MANLAB | And 2 more authors.
Acta Bioquimica Clinica Latinoamericana

Six hepatitis C virus genotypes have been identified worldwide so far. These genotypes have been subclassified into different subtypes (a, b, c and others). It is known that the response to treatment is highly dependent on the genotype involved. The aim of this work was to assess the frequency of occurrence of the different HCV genotypes in the population of Argentina. To this end, 510 infected patients were subjected to HCV genotyping using the commercial kit Versant HCV genotype assay 2.0. Results indicated that the genotype 1 was the most frequent (67.6%), and that subtypes 1a and 1b showed a similar prevalence (33.3% and 34.5%, respectively). Genotypes 2 and 3 also displayed a similar frequency (14.5% and 14.5% respectively). This study provides an update regarding the frequency of all HCV genotypes circulating in Argentina. The results were obtained by the novel version of the genotyping kit, which enabled a correct subtyping of samples. Source

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