Laboratorio Interdisciplinar em Fisiologia e Exercicio LAIFE

São Paulo, Brazil

Laboratorio Interdisciplinar em Fisiologia e Exercicio LAIFE

São Paulo, Brazil
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Monico-Neto M.,Laboratorio Interdisciplinar em Fisiologia e Exercicio LAIFE | Dattilo M.,Laboratorio Interdisciplinar em Fisiologia e Exercicio LAIFE | Lee K.S.,University of Sao Paulo | de Mello M.T.,Federal University of Minas Gerais | Antunes H.K.M.,Laboratorio Interdisciplinar em Fisiologia e Exercicio LAIFE
Growth Factors | Year: 2017

Introduction: The aim was observe the influence of sleep deprivation (SD) and sleep recovery on muscle regeneration process in rats submitted to cryolesion. Methods: Thirty-two Wistar rats were randomly allocated in four groups: control (CTL), SD for 96 h (SD96), control plus sleep recovery period (CTL + R) and SD96h plus 96 h of sleep recovery (SD96 + R). The animals were submitted to muscle injury by cryolesioning, after to SD and sleep recovery. Results: The major outcomes of this study were the reduction of muscular IGF-1 in both legs (injured and uninjured) and a delay in muscle regeneration process of animals submitted to SD compared to animals that slept, with increase connective tissue, inflammatory infiltrate and minor muscle fibers. Conclusions: SD impairs muscle regeneration in rats, moreover reduces muscular IGF-1 and sleep recovery was able to restore it to basal levels, but it was not enough to normalize the muscle regeneration. © 2017 Informa UK Limited, trading as Taylor & Francis Group.

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