Laboratories of Cellular and Molecular Neurobiology and of Neuroembryology

Santa Lucia di Serino, Italy

Laboratories of Cellular and Molecular Neurobiology and of Neuroembryology

Santa Lucia di Serino, Italy
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Svetoni F.,Foro Italico University of Rome | Svetoni F.,Laboratories of Cellular and Molecular Neurobiology and of Neuroembryology | de Paola E.,Foro Italico University of Rome | de Paola E.,Laboratories of Cellular and Molecular Neurobiology and of Neuroembryology | And 9 more authors.
Human Molecular Genetics | Year: 2017

Brain development involves proliferation, migration and specification of neural progenitor cells, culminating in neuronal circuit formation. Mounting evidence indicates that improper regulation of RNA binding proteins (RBPs), including members of the FET (FUS, EWS, TAF15) family, results in defective cortical development and/or neurodegenerative disorders. However, in spite of their physiological relevance, the precise pattern of FET protein expression in developing neurons is largely unknown. Herein, we found that FUS, EWS and TAF15 expression is differentially regulated during brain development, both in time and in space. In particular, our study identifies a fine-tuned regulation of FUS and EWS during neuronal differentiation, whereas TAF15 appears to be more constitutively expressed. Mechanistically FUS and EWS protein expression is regulated at the post-transcriptional level during neuron differentiation and brain development. Moreover, we identified miR-141 as a key regulator of these FET proteins that modulate their expression levels in differentiating neuronal cells. Thus, our studies uncover a novel link between post-transcriptional regulation of FET proteins expression and neurogenesis. © The Author 2017.

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