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Galvan A.B.,Laboratori Of Citogenetica Molecular Servei Of Patologia | Galvan A.B.,Autonomous University of Barcelona | Mallo M.,Laboratori Of Citogenetica Molecular Servei Of Patologia | Mallo M.,Autonomous University of Barcelona | And 8 more authors.
Leukemia Research | Year: 2010

Abnormalities of chromosome 5 are common aberrations in myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML), being del(5q) the most frequent. In contrast, monosomy 5 is not so frequent and, usually, is associated with complex karyotypes, conferring poor prognosis. The aim of this study was to analyze, by FISH for 5q31 (EGR1), a series of 28 MDS and AML cases with monosomy 5 detected by G-banding. FISH results revealed deletion of 5q31 in 24 of them (85.7%) and monosomy 5 just in three. FISH for 5q31 can complement conventional cytogenetics and improve the karyotype definition, leading to a better diagnostic and prognostic stratification. © 2010 Elsevier Ltd.

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