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Guell I.,Laboratori Dinnovacio En Processos I Productes Of Sintesi Organica Lippso | Vila S.,Laboratori Dinnovacio En Processos I Productes Of Sintesi Organica Lippso | Micalo L.,Laboratori Dinnovacio En Processos I Productes Of Sintesi Organica Lippso | Badosa E.,Institute Of Food And Agricultural Technology Cidsav Certa | And 3 more authors.
European Journal of Organic Chemistry | Year: 2013

Cyclic peptidotriazoles derived from the antimicrobial cyclic peptide c(Lys-Lys-Leu-Lys-Lys-Phe-Lys-Lys-Leu-Gln) (BPC194) were prepared by incorporating a triazolyl amino acid at the 3-position. The synthesis was accomplished on solid-phase and involved as the key step a copper-catalyzed cycloaddition reaction between a resin-bound alkyne or a resin-bound azide and a range of azides or alkynes in solution, respectively. This methodology was also applied to the synthesis of a conjugated peptide containing a cyclic and a linear peptidyl sequence linked through a triazolyl ring. Cyclic peptidotriazoles were obtained in excellent purities starting either from an alkynyl or an azido peptidyl resin. These compounds were screened in vitro for their growth inhibition of bacterial phytopathogens and for their cytotoxic effects on eukaryotic cells. Peptide sequences with high antibacterial activity and low hemolysis were identified, constituting good candidates for the design of new antimicrobial agents. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

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