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L'Hospitalet de Llobregat, Spain

Juncosa-Morros T.,Hospital Universitari Sant Joan Of Deu | Guardia-Llobet C.,Laboratori Barcelones Nord I Valles Oriental | Bosch-Mestres J.,Servicio de Microbiologia | Dopico-Ponte E.,Laboratori Clinic Of Lhospitalet | And 6 more authors.
Enfermedades Infecciosas y Microbiologia Clinica | Year: 2014

Objetive: To study the characteristics and evolution of group B Streptococcus (GBS) late-onset diseases, over a period of 15 years in 8 hospitals the Barcelona area and analyze the possible impact of prophylactic measures for the prevention of early-onset neonatal infections. Methods: Retrospective review of all patients diagnosed with late-onset neonatal disease due to GBS from 1996 to 2010. Results: A total of 143 patients were diagnosed. Of these, 51 were born in others hospitals. The overalll incidence was 0.42 per 1000 live births, varying between 0.14‰ in the year 2000 and 0.80‰ in 2009. A slight but sustained tendency of increased risk was observed over the years, 6.9% in the overall disease (with no statistical signi.cance). Sepsis/bacteremia was detected in 63.6% of the newborns, meningitis in 32.8%, and arthritis/osteomyelitis in 3.5%. In cases with known obstetrics dates, 53% of mothers had been colonized by GBS during pregnancy, 53.8% received intrapartum antibiotic prophylaxis, and 41.2% had some obstetric risk factors, particularly premature birth in 35.9%. There was a 2.8% mortality rate in the neonates, and predominant serotypes were III and Ia. Conclusions: The incidence of GBS late-onset disease has not decreased despite the control practices of early-onset disease, and possibility of this appearing must be taken into account. © 2013 Elsevier España, S.L.U. Todos los derechos reservados. Source

Gimenez M.,Hospital Universitari Germans Trias i Pujol | Sanfeliu I.,Servicio de Microbiologia | Sierra M.,Servicio de Microbiologia | Dopico E.,Laboratori Clinic Of Lhospitalet | And 6 more authors.
Enfermedades Infecciosas y Microbiologia Clinica Monografias | Year: 2015

Objectives: To study the evolution of the incidence of early-onset neonatal sepsis (EOS) by Streptococcus agalactiae in the area of Barcelona and to analyze failure of compliance with the prevention protocol. Methods: A retrospective review was carried out on EOS cases in 8 Health-Care Centers in the Barcelona area between 2004 and 2010. Results: Forty-nine newborns from 48 mothers were diagnosed with EOS. The incidence was 0.29‰ living newborns (0.18-0.47‰), with no significant differences in the fluctuations along the 7 years. The mortality rate was 8.16%. In 68.5% cases the maternal colonization studies were negative, and in 21% these studies were not performed. No risk factors were detected in 58.3% of pregnant women, and 22.9% of births were premature. In 58% of cases intra-partum antibiotic prophylaxis was not administered because it was not indicated, and in 42% due to failure to follow the protocol (3 strains were resistant to erythromycin). Resistance to clindamycin was 33.3%. The Streptococcus agalactiae serotypes more frequently isolated were iii, v, and ia. Conclusions: No significant changes were detected in the incidence of Streptococcus agalactiae EOS in the 7 years of the study. The increased sensitivity of screening methods with the use of molecular techniques, the performance of susceptibility testing of strains isolated from pregnant women, and the improvement of communication between Health-Care Centers, can contribute to a better implementation of the protocol, as well as to reduce the incidence of EOS. © 2014 Elsevier España, S.L.U. Source

Gonzalez V.,Center for Epidemiological Studies on in Catalonia CEEISCAT | Gonzalez V.,Autonomous University of Barcelona | Gonzalez V.,CIBER ISCIII | Fernandez G.,Autonomous University of Barcelona | And 8 more authors.
Journal of Clinical Microbiology | Year: 2015

We report here the results of the diagnostic performances of Vitros Syphilis TPA (a chemiluminescence treponemal assay) compared with those of two treponemal enzyme immunoassays and of traditional versus reverse syphilis algorithms. Ease of use, automation, and high throughput make the Vitros Syphilis TPA assay a good choice for syphilis screening in high-volume laboratories. Copyright © 2015, American Society for Microbiology. All Rights Reserved. Source

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