Laboratoires Expanscience

Épernon, France

Laboratoires Expanscience

Épernon, France
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Patent
Laboratoires Expanscience | Date: 2017-02-08

The invention relates to biomarkers of the skin of children and, in particular, that of infants, having altered expression in the presence of urine. Such markers are particularly advantageous as they allow the skins response to urine to be monitored. The inventors have developed methods for evaluating the efficacy in vitro of formulations in preventing the harmful effects of urine on a childs skin, using a skin model specifically capable of reproducing the characteristics of childrens skin.


Patent
Laboratoires Expanscience | Date: 2017-03-22

The present invention relates to a method for determining the relief of the skin surface of a subject, and hence the degree of maturation of the said skin surface. Methods for identifying active agents, raw materials and formulation are also provided.


Patent
Laboratoires Expanscience | Date: 2015-07-03

The present invention relates to the use of a lupin peptide extract to prevent loss of skin firmness or to increase the firmness of skin. Advantageously, the lupin peptide extract can prevent the appearance of cellulite and/or reduce skin cellulite.


Patent
Laboratoires Expanscience | Date: 2017-05-10

The present invention relates to the use of a lupin peptide extract to prevent loss of skin firmness or to increase the firmness of skin. Advantageously, the lupin peptide extract can prevent the appearance of cellulite and/or reduce skin cellulite.


Patent
Laboratoires Expanscience | Date: 2015-03-04

The present invention thus relates to a method for determining the degree of maturation of the skin surface of a subject. In particular, the present invention relates to method for determining whether the skin surface of a subject is mature/immature in its organization/function, said method comprising the steps of taking a skin sample of the said subject; and determining the corneodesmosome distribution within the stratum corneum of the sample.


Patent
Laboratoires Expanscience | Date: 2015-01-12

A first subject of the invention is a skin model characterized in that it comprises keratinocytes capable of overexpressing filaggrin. A second subject of the invention is a method for evaluating the in vitro activity of a formulation or of at least one active agent on the healing of nipple skin and/or on the reduction of nipple skin inflammation, characterized in that said method comprises at least the following steps: a) bringing said active agent or said formulation into contact with a skin model comprising keratinocytes overexpressing filaggrin and also comprising a lesion; b) measuring the level of production of at least one biological marker in the nipple skin model of step a), characterized in that said biological marker can be chosen from lactate dehydrogenase (LDH), TNF, filaggrin, TGF1 and 1 integrin; c) comparing the level of production of at least one biological marker obtained in step b) with a reference level of production; evaluating the efficacy of said active agent or of said formulation according to the comparison of step c).


The invention concerns a use of C7 sugars and derivatives of formula (I), called avocado perseose, which have, inter alia, a protective activity to epidermal skin cells. These C7 sugars and derivatives are capable of maintaining the expression of markers of adult stem cells, in particular basal stem cells. Avocado perseose can also be used for preventing the deleterious effects of environmental damage. Avocado perseose has a beneficial effect on the conservation of the potential of epidermal stem cells and thus helps maintain skin homeostasis.


Patent
Laboratoires Expanscience | Date: 2015-11-18

The present invention relates to a method for determining the relief of the skin surface of a subject, and hence the degree of maturation of the said skin surface. Methods for identifying active agents, raw materials and formulation are also provided.


Patent
Laboratoires Expanscience | Date: 2014-09-25

The invention relates to a lipid extract of the seeds of passion fruit, Passiflora incarnata and/or Passiflora edulis, preferably P. edulis, characterised in that said lipid extract is an oil of passion fruit seeds concentrated in its unsaponifiable fraction, containing between 3 wt. % and 100 wt. % of unsaponifiable matter in relation to the total weight of the extract. The invention also relates to a method for preparing such an extract and to a composition comprising said extract, especially for the use thereof in a dermatological or pharmaceutical composition or as a food.


Patent
Laboratoires Expanscience | Date: 2014-04-22

The invention relates to a method for evaluating the effectiveness of an active ingredient selected from C7 avocado sugars, also called avocado perseose, for preventing or treating a deficiency of the skin barrier, said method comprising the determination of the level of expression and/or activation of at least one biological marker, where said biological marker is selected from epidermal maturation markers, lipid barrier markers, hydric regulation markers and stratum granulosum regulation markers.

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