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Raeppel S.L.,Laboratoires ChemRF Inc. | Therrien E.,Laboratoires ChemRF Inc. | Therrien E.,Molecular Forecaster Inc. | Raeppel F.,Laboratoires ChemRF Inc.
Bioorganic and Medicinal Chemistry Letters | Year: 2015

Abstract New fused bicyclic lactam head groups as rigidified analogs of thieno[3,2-b]pyridine-based kinase inhibitor LCRF-0004 were designed and synthesized. Depending on the functionalities and the size of these bicyclic head groups, potent inhibitors of RON tyrosine kinase with various level of selectivity against c-Met tyrosine kinase were obtained. © 2015 Elsevier Ltd. Source


Raeppel F.,Laboratoires ChemRF Inc. | Raeppel S.L.,Laboratoires ChemRF Inc. | Therrien E.,Laboratoires ChemRF Inc. | Therrien E.,Molecular Forecaster Inc.
Bioorganic and Medicinal Chemistry Letters | Year: 2015

New heteroarylcarboxamide head groups substituted with two aromatic rings analogs of thieno[3,2-b]pyridine-based kinase inhibitor LCRF-0004 were designed and synthesized. Potent inhibitors of RON tyrosine kinase with various level of selectivity for c-Met RTK were obtained. © 2015 Elsevier Ltd. Source

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