Laboratoire Synthese et Reactivite des Substances Naturelles

Poitiers, France

Laboratoire Synthese et Reactivite des Substances Naturelles

Poitiers, France

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Soro Y.,Félix Houphouët-Boigny National Polytechnic Institute | Kassi A.B.B.,Félix Houphouët-Boigny National Polytechnic Institute | Bamba F.,University Of Cocody | Siaka S.,Félix Houphouët-Boigny National Polytechnic Institute | And 2 more authors.
Rasayan Journal of Chemistry | Year: 2012

Fractionation of the ethyl acetate fraction of the ethanolic extract of the dried powdered leaves of Santaloides afzelii (Connaraceae) on silica gel column chromatography afforded gallic acid and two flavonoids glycosides identified as quercetin-3-O-rhamnoside and myricetin-3-O-rhamnoside. Their structures were elucidated by 'H and 13C-NMR data and UV data. It is the first time that these compounds are reported in the plant. © 2012 RASÄYAN. All rights reserved.


Liu F.,Laboratoire Synthese et Reactivite des Substances Naturelles | Martin-Mingot A.,Laboratoire Synthese et Reactivite des Substances Naturelles | Jouannetaud M.-P.,Laboratoire Synthese et Reactivite des Substances Naturelles | Bachmann C.,UMR 6503 | And 3 more authors.
Journal of Organic Chemistry | Year: 2011

The first direct selective synthesis of novel gem-chlorofluorinated nitrogen-containing building blocks in superacid is reported. The dramatic role of the chlorine atom on the reaction is shown by in situ NMR experiments and allows the involvement of a novel original superelectrophilic activation process in superacid HF/SbF5 to be postulated.(Figure Presented) © 2011 American Chemical Society.


Liu F.,Laboratoire Synthese et Reactivite des Substances Naturelles | Martin-Mingot A.,Laboratoire Synthese et Reactivite des Substances Naturelles | Jouannetaud M.-P.,Laboratoire Synthese et Reactivite des Substances Naturelles | Zunino F.,Rtmolecule | Thibaudeau S.,Laboratoire Synthese et Reactivite des Substances Naturelles
Organic Letters | Year: 2010

(Figure Presented) The synthesis of benzofused sultams and/or fluorlnated sulfonamides, starting from N-allyllc sulfonamides, was performed In superacid HF/ SbF5, through superelectrophilic activation. A dramatic effect of superacid composition on the selectivity of the reaction was shown and applied to the synthesis of cyclic 4-aminobenzenesulfonamides. © 2010 American Chemical Society.


PubMed | Laboratoire Synthese et Reactivite des Substances Naturelles
Type: Journal Article | Journal: Journal of enzyme inhibition and medicinal chemistry | Year: 2012

A series of benzofused sultams and fluorinated benzenesulfonamides were synthesized in superacid HF/SbF(5) from simple N-allylic derivatives. Almost all of these original compounds showed micromolar inhibitory activities against carbonic anhydrases I and II. The fluorinated derivatives inhibit better the tumor-associated isoforms IX and XII, and one of the tested compounds showed inhibition in the nanomolar range.


PubMed | Laboratoire Synthese et Reactivite des Substances Naturelles
Type: Journal Article | Journal: Organic letters | Year: 2010

The synthesis of benzofused sultams and/or fluorinated sulfonamides, starting from N-allylic sulfonamides, was performed in superacid HF/SbF(5), through superelectrophilic activation. A dramatic effect of superacid composition on the selectivity of the reaction was shown and applied to the synthesis of cyclic 4-aminobenzenesulfonamides.


PubMed | Laboratoire Synthese et Reactivite des Substances Naturelles
Type: Journal Article | Journal: The Journal of organic chemistry | Year: 2011

The first direct selective synthesis of novel gem-chlorofluorinated nitrogen-containing building blocks in superacid is reported. The dramatic role of the chlorine atom on the reaction is shown by in situ NMR experiments and allows the involvement of a novel original superelectrophilic activation process in superacid HF/SbF(5) to be postulated.

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