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Clermont-Ferrand, France

Jarde T.,University of Cardiff | Perrier S.,Laboratoire SVFp | Vasson M.-P.,EA 4233 | Vasson M.-P.,Center Jean Perrin | Caldefie-Chezet F.,Laboratoire SVFp
European Journal of Cancer | Year: 2011

Obesity is associated with an increased risk of breast cancer in postmenopausal women. Accumulating evidence suggests that adipose tissue, which is an endocrine organ producing a large range of factors, may interfere with breast cancer development. Leptin and adiponectin are two major adipocyte-secreted hormones. The pro-carcinogenic effect of leptin and conversely, the anti-carcinogenic effect of adiponectin result from two main mechanisms: a modulation in the signalling pathways involved in proliferation process and a subtle regulation of the apoptotic response. This review provides insight into recent findings on the molecular mechanisms of leptin and adiponectin in mammary tumours, and discusses the potential interplay between these two adipokines in breast cancer. © 2010 Elsevier Ltd. All rights reserved. Source

Dubois V.,Laboratoire SVFp | Dubois V.,University of Auvergne | Delort L.,Laboratoire SVFp | Delort L.,University of Auvergne | And 12 more authors.
Anticancer Research | Year: 2010

Background/aim: Obesity increases the risk of breast cancer. It is established that adipocyte secretions, i.e. adipokines, may play a role in mammary carcinogenesis. We have shown that two major adipokines, leptin and adiponectin, were expressed in mammary adenocarcinoma. Patients and Methods: Here, we evaluated zinc-α2-glycoprotein (ZAG) expression in tumor (n=55) and healthy (n=6) breast tissue by immunohistochemistry and examined whether it was correlated with that of major adipokines, usual tumor biomarkers (sex steroids receptors, i.e. estrogen (ER) and progesterone; Ki-67; cErb2), or apoptosis markers (Bcl2 and Bax). Results: ZAG expression was detected in ductal carcinoma and normal epithelial adjacent tissue but not in normal tissue of healthy women. In cancer tissue, its expression was correlated positively to leptin receptor and negatively to adiponectin receptor and ER. Conclusion: These preliminary results suggest both a relationship between ZAG expression and pathways involving adipokines or estrogen and that ZAG may be a potential breast cancer biomarker. Source

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