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Ourari A.,Ferhat Abbas University Setif | Baameur L.,Ferhat Abbas University Setif | Bouacida S.,University of Mentouri Constantine | Gilles B.,Laboratoire SONAS | Magali A.,French National Center for Scientific Research
Acta Crystallographica Section E: Structure Reports Online | Year: 2012

The title molecule, C16H12Cl4N 2O2, lies about an inversion center. The symmetry-unique part of the molecule contains an intramolecular O - H⋯N hydrogen bond. In the crystal, molecules are arranged in corrugated layers parallel to (1̄01). Weak π-π stacking interactions, with a centroid-centroid diatance of 3.7923 (13) Å, are present.


Alomar K.,Laboratoire SONAS | Gaumet V.,French Institute of Health and Medical Research | Allain M.,University of Angers | Richomme P.,Laboratoire SONAS | Bouet G.,Laboratoire SONAS
Inorganica Chimica Acta | Year: 2012

Reacting with nickel(II) chloride, copper(II) chloride and bromide, thiophene-2,3-dicarboxaldehyde bis(oxime) (2,3BTCOH 2) leads to metal complexes formulated as [NiCl 2(2,3BTCOH 2)], [CuCl 2(2,3BTCOH 2)] and [CuBr(2,3BTCOH)] 2 respectively. In the case of nickel(II) bromide, we have observed the rearrangement of 2,3BTCOH 2 into 2-acetamido-3-thiophene carboxaldoxime (ACTOH) instead of the expected complex. The crystal structures of 2,3BTCOH 2 and ACTOH have been determined by X-ray diffraction methods and all other structures are proposed using usual spectroscopic techniques. © 2012 Elsevier B.V. All rights reserved.


Alomar K.,Laboratoire SONAS | Gaumet V.,French Institute of Health and Medical Research | Allain M.,CNRS Angers Institute of Molecular Science and Technology | Bouet G.,Laboratoire SONAS | Landreau A.,Laboratoire SONAS
Journal of Inorganic Biochemistry | Year: 2012

The reaction of nickel (II) chloride and bromide with 3-thiophene aldehyde semicarbazone (3STCH) and 2,3-thiophene dicarboxaldehyde bis(semicarbazone) (2,3BSTCH2) leads to the formation of a series of new complexes: [NiCl2(3STCH)2], [NiBr2(3STCH)2], [NiCl(2,3BSTCH2)(H2O)]Cl, and [NiBr(2,3BSTCH 2)(H2O)]Br respectively. The crystal structures of the two ligands 3STCH, 2,3BSTCH2 and of the complex [NiBr(2,3BSTCH 2)(H2O)]Br have been determined by X-ray diffraction methods. For all these complexes, the central ion is coordinated through the oxygen atom of the carbonyle and the azomethine nitrogen atom of the semicarbazone. The antifungal activity of the complexes and their corresponding ligands was evaluated against some strains of respectively, Candida albicans, Candida glabrata and Aspergillus fumigatus. The complexes with 3STCH and 2,3BSTCH2 revealed interesting CMI80 values specifically against C. glabrata. Cytotoxicity assay was also carried out in vitro on MRC5 cells. © 2012 Elsevier Inc. All rights reserved.


Aliouane N.,Laboratoire dElectrochimie des Materiaux Moleculaires et des Complexes | Chafaa S.,Laboratoire dElectrochimie des Materiaux Moleculaires et des Complexes | Douadi T.,Laboratoire dElectrochimie des Materiaux Moleculaires et des Complexes | Helesbeux J.-J.,Laboratoire SONAS | And 3 more authors.
Heteroatom Chemistry | Year: 2010

The acido-basic and the complexation properties of di-, tri-, and tetra-phosphonic acids (H6L1, H8L2, and H10L3) toward Fe(III) and Cu(II) were determined by potentiometric titration in aqueousmedia at 25.0 ± 0.1°Cwith constant ionic strength (0.1 M, NaClO4). We have determined six, ten, and eight pKa values for the di, tri, and tetra-phosphonic acids, respectively. In acidic conditions, e.g., 0 ≤ pH ≤ 5; iron and copper presented a high affinity toward these ligands to give complex species. With the ligand H10L3, [FeL3H7], and [CuL3H6]2-were easily obtained at pH 1.8 and 2.7, respectively. We have determined ten stability constants for the H10L3/Fe system and nine for the H10L3/Cu one; six and four in the cases of H8L2/Fe and H8L2/Cu systems, respectively. Finally, five stability constants were calculated for the H 6L1/Fe system and four for the H6L1/Cu one. We have not observed any insoluble species in these complexes in acidic medium as well as in alkaline solutions. © 2010 Wiley Periodicals, Inc.


Ourari A.,Ferhat Abbas University Setif | Baameur L.,Ferhat Abbas University Setif | Bouet G.,Laboratoire SONAS | Allain M.,French National Center for Scientific Research
Acta Crystallographica Section E: Structure Reports Online | Year: 2012

In the title Schiff base, C29H26N2O 4, the complete molecule is generated by a crystallographic twofold axis and is V-shaped. The planes of the benzene rings of the central diphenyl-methane unit make a dihedral angle of 78.11 (4)° while adjacent benzene and 5-meth-oxy-salicyl-idene rings are twisted with respect to each other by a dihedral angle of 11.84 (8)°. The Schiff base is in the enol-imino form and an intra-molecular O-H⋯N hydrogen bond is observed.


PubMed | Laboratoire SONAS
Type: Journal Article | Journal: Journal of enzyme inhibition and medicinal chemistry | Year: 2010

The semisynthesis of xanthanolide derivatives is reported from xanthinin and 4-epi-isoxanthanol, two sesquiterpene lactones isolated from the crude chloroformic extract of the leaves of Xanthium macrocarpum DC. (Asteraceae) by liquid/liquid chromatography. In vitro evaluation of their protein farnesyltransferase (PFTase) inhibitory activity has been investigated. In contrast to other biological activities of xanthanolides, PFTase inhibition is not associated with the presence of the potentially toxic alpha-methylene-gamma-lactone function.

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