Laboratoire Of Synthese Organique Et Heterocyclique

Tunis, Tunisia

Laboratoire Of Synthese Organique Et Heterocyclique

Tunis, Tunisia
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Saied T.,French National Center for Scientific Research | Saied T.,Laboratoire Of Synthese Organique Et Heterocyclique | Jelaiel N.,Laboratoire Of Synthese Organique Et Heterocyclique | Efrit M.L.,Laboratoire Of Synthese Organique Et Heterocyclique | And 2 more authors.
Tetrahedron | Year: 2017

We report herein a short and efficient synthesis of benz[e][1,2,4]- or [d][1,2,6]oxadiazepines and benzo[f][1,3,5]triazocines from easily prepared N-aryl iminoesters. The strategy involves a bis-nucleophile reagent (hydroxylamine or guanidine) that promotes a one-step ring closure from the starting functionalized iminoesters. © 2017 Elsevier Ltd


Jelaiel N.,CNRS Structure and Reactivity of Complex Molecular Systems | Jelaiel N.,Laboratoire Of Synthese Organique Et Heterocyclique | Comoy C.,CNRS Structure and Reactivity of Complex Molecular Systems | Fernette B.,CNRS Structure and Reactivity of Complex Molecular Systems | And 2 more authors.
Tetrahedron | Year: 2011

We described in this paper an efficient synthesis of variously substituted 4-phosphinoyl-4,5,6,7-tetrahydro-2H-indazol-3-ylamines involving nucleophilic addition of hydrazine on β-ketothioamides as key-step. © 2011 Elsevier Ltd. All rights reserved.


Besbes N.,Center national des recherches en science des materiaux | Jellali H.,Center national des recherches en science des materiaux | Pale P.,CNRS Institute of Chemistry | Srasra E.,Center national des recherches en science des materiaux | Efrit M.L.,Laboratoire Of Synthese Organique Et Heterocyclique
Comptes Rendus Chimie | Year: 2010

The silica gel, neutral alumina and acid activated clays transform the N-acyl-2,2-dimethylaziridines 1 into a mixture of N-methallylamides 2, oxazolines 3 and amidoalcohols 4. The reaction of N-benzoyl-2,2-dimethylaziridine with benzylcyanid anion leads to a mixture of amidopyrroline 5 and iminopyrrolidine 6. The product 5 was converted into its tautomer 6 by chromatogaphy on silica gel. Ionic mechanisms were then proposed to explain the formation of products 2-6 resulting from the regioselective ring opening on the more substituted C2 carbon side. © 2009 Académie des sciences.


Besbes N.,Center National des Recherches en science des Materiaux | Jellali H.,Center National des Recherches en science des Materiaux | Pale P.,CNRS Institute of Chemistry | Efrit M.L.,Laboratoire Of Synthese Organique Et Heterocyclique | Srasra E.,Center National des Recherches en science des Materiaux
Phosphorus, Sulfur and Silicon and the Related Elements | Year: 2010

Silica gel and activated clay, behaving as Lewis acids, reacted with N-acyl-2,2-dimethylaziridines 1 to lead to pentacoordinated aziridinium silicate ions. The regiospecific ring opening on the CMe2 carbon side of the intermediate I involves, after removal of the catalyst, the zwitterion II. The zwitterion II undergoes either a transfer of proton leading to the N-methallylamide 2 or intramolecular cyclization reaction leading to the oxazoline 3. The unstable oxazoline 3 on catalyst is hydrated in turn into amidoalcohol 4 via the oxazolinium silicate III.


Jelaiel N.,Laboratoire Of Synthese Organique Et Heterocyclique | Said N.,Laboratoire Of Synthese Organique Et Heterocyclique | Touil S.,Laboratoire Of Synthese Organique Et Heterocyclique | Efrit M.L.,Laboratoire Of Synthese Organique Et Heterocyclique
Phosphorus, Sulfur and Silicon and the Related Elements | Year: 2010

The condensation of primary amines on - or -ketophosphonates affords the corresponding iminophosphonates. The reaction was found to be highly stereoselective, affording the E isomer exclusively. These phosphonylimines were then treated in basic media to give pyrrolidines and quinolines through intramolecular cyclization. The structures of all obtained products were confirmed by NMR spectroscopy (1H, 31P, 13C), and in some cases by mass spectrometry. Copyright © Taylor & Francis Group, LLC.

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