Mezni I.,French Institute of Health and Medical Research |
Mezni I.,Laboratoire Of Recherche Dimmunologie Of La Transplantation Renale Et Dimmunopathologie |
Galichon P.,French Institute of Health and Medical Research |
Bacha M.M.,Laboratoire Of Recherche Dimmunologie Of La Transplantation Renale Et Dimmunopathologie |
And 8 more authors.
Medecine/Sciences | Year: 2015
Epithelial-mesenchymal transition (EMT) is a process by which differentiated epithelial cells undergo a phenotypic conversion and acquire a mesenchymal phenotype, including elongated morphology, enhanced migratory and invasion capacity, and greatly increased production of extracellular matrix (ECM) components. This phenomenon plays a pivotal role in embryonic development, wound healing and tissue regeneration. It has also been involved in organ fibrosis. Some studies suggest that following injury, renal tubular epithelial cells undergo reprograming in mesenchymal cells, and thus constitute an important source of de novo myofibroblasts invading the renal interstitium and contributing to fibrosis. However, an increasing number of studies raise doubts about the existence of this process in vivo. The role of EMT in the development of renal fibrosis remains a matter of intense debate and may depend on the model studied. In this review, we describe the role of EMT in the development of fibrosis of renal graft, and then we propose approaches for detecting and treating renal fibrogenesis by targeting TEM. © 2015 médecine/sciences-Inserm. Source