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El Elj N.,University of Tunis | Lac G.,University Blaise Pascal | Tabka Z.,Laboratoire Of Physiologie Et Des Explorations Fonctionnelles | Gharbi N.,University of Tunis | El Fezaa S.,University of Tunis
Procedia - Social and Behavioral Sciences | Year: 2011

The prevalence of obesity and associated health conditions is increasing, which underscores the importance of developing effective strategies to counteract overweight. It is well known that diet and exercise are the two main ways to loose weight. It is not known, however, how exercise training can induce weight loss. To test this, we compared the combined effect of 30 days of two different diets and exercise training on weight loss enhancement. The study was carried out on four groups of rats (n=12); the standard diet sedentary group (SS), standard diet with exercise (SE), high-protein diet with exercise (PE) and high-fat diet with exercise (FE). Significant reductions in weight gain and in food intake were observed with training (p<0.001). Body weight was decreased by protein diet (p<0.01) and increased by fat diet (p<0.001). Fat-diet increased both insulin concentrations (p<0.05), glycaemia (p<0.001) and muscle glycogen (p<0.01). Our results demonstrated the positive effect of physical exercise on reducing both food intake and weight gain. We showed, as well, that combined effect of protein diet and exercise training induced the greatest weight loss. Fat diet, on the contrary, disrupts carbohydrate and fat metabolism and promotes overweight. © 2011 Published by Elsevier Ltd. Source


Chaouache N.,Laboratoire Of Physiologie Et Des Explorations Fonctionnelles | Ajina M.,Unite de medecine de la reproduction | Gaddas M.,Laboratoire Of Physiologie Et Des Explorations Fonctionnelles | Miled A.,Service de biochimie | And 3 more authors.
Nutrition Clinique et Metabolisme | Year: 2015

Objectives: The importance of maternal metabolic environment for a correct embryonic development has not been well explored until now. The objective of our work is to determine the metabolic profile impact on biological results of assisted reproductive technology (ART) in infertile women of different weights. Patients and methods: Forty patients undergoing ART cycles were divided into three groups (control group, overweight group and obese group) according to the body mass index. Blood samples were measured on the day of oocyte retrieval for biochemical analyses of glucose, total cholesterol, triglycerides and High-density lipoprotein. The biological parameters measured were: total number of oocytes, number of zygotes, oocyte quality, embryo quality, and fertilization and segmentation rates. Results: Disturbances in metabolic profile were found in obese women accompanied by poor reproductive outcomes, compared to other groups. Hypertriglyceridemia found in the obese group was negatively correlated with embryo quality (r= 0.33; P= 0.037) and fertilization rate (r= 0.3; P= 0.048). High glucose and cholesterol levels were accompanied by poor oocyte maturity, poor embryo quality and a low fertilization rate. Conclusion: In conclusion, evidence has been shown to suggest that hypertriglyceridemia, high cholosterol, and high glycemia levels in obese women have a negative effect on the success of in vitro fertilization. As such, appropriate nutritional care and metabolic syndrome screening could improve the ART result among obese. © 2015 Elsevier Masson SAS. Source


El Elj N.,University of Tunis | Lac G.,University Blaise Pascal | Alya B.,University of Tunis | Lasram M.,University of Tunis | And 5 more authors.
Annales d'Endocrinologie | Year: 2010

Objectives: Although it is known that circulating levels of insulin-like growth factor-1 (IGF-1) are influenced by both physical exercise and dietary intake separately, there is little information regarding the additive effect of diets and training on IGF-1 regulation. To test this, we examined the combined effect of 30 days of two different diets (high-protein and high-carbohydrate) and exercise training on total IGF-1. Materials and methods: The study was carried out with four groups of rats; the sedentary group with standard diet (SS) (control group), standard diet with exercise (SE), high-protein diet with exercise (PE) and high-carbohydrate diet with exercise (CE). Serum IGF-1, insulin, corticosterone were analyzed. Results: IGF-1 concentrations were decreased by exercise training (p<0.001) and only with protein diet (p<0.05). Physical training, with and without diet, decreased body weight and food intake (p<0.01) and increased corticosterone levels (p<0.05). Carbohydrate diet did not cause major hormonal and metabolic alterations. Conclusion: The main result of this study was the decreased levels of IGF-1 in spite of high-protein diet, which is known to enhance IGF-1 secretion, and the little changes with carbohydrate diet. This may be related to the negative energy balance as a result of the catabolic state induced by exercise training and decreased calorie intake in protein diet. Thus, it can be concluded that the caloric restriction, regardless of dietary composition, decreased IGF-1 secretion. © 2010 Elsevier Masson SAS. Source


El Elj N.,University of Tunis | Lac G.,University Blaise Pascal | Zaouali M.,Laboratoire Of Physiologie Et Des Explorations Fonctionnelles | Tabka Z.,Laboratoire Of Physiologie Et Des Explorations Fonctionnelles | And 2 more authors.
Science and Sports | Year: 2012

Objective: The prevalence of obesity and associated health conditions is increasing, which underscores the importance of developing effective strategies to counteract overweight. It is well known that diet and exercise are the two main ways to control weight gain. It is not known, however, how physical exercise can prevent overweight when associated with different types of diets. To test this, we compared the combined effect of 30 days of two different diets and exercise training on total weight change in rats. Material and methods: The study was carried out on four groups of rats (n=12), 6 weeks old; the standard diet sedentary group (SS), standard diet with exercise (SE), high-protein diet with exercise (PE) and high-fat diet with exercise (FE). Results: Significant reductions in weight gain and in food intake were observed with training (P<. 0.001). Body weight was decreased by protein diet (P<. 0.01) and maintained in trained rats receiving fat diet. Fat diet increased both insulin concentrations (P<. 0.05), glycaemia (P<. 0.001) and muscle glycogen (P<. 0.01). Conclusion: Our results demonstrated the positive effect of physical exercise on reducing both food intake and weight gain in the case of standard diet. We showed, as well, that combined effect of exercise training with hypocaloric diet (protein diet) induced the less weight gain. Whereas, in combination with hypercaloric diet (Fat diet), physical exercise prevented overweight. Fat diet disrupts, also, carbohydrate and fat metabolisms. © 2011 Elsevier Masson SAS. Source


Lazreg T.B.,Laboratoire Of Physiologie Et Des Explorations Fonctionnelles | Chaefeddine I.B.,Laboratoire Of Cytogenetique | Gribaa M.,Laboratoire Of Cytogenetique | Naiija O.,Service de reanimation | And 2 more authors.
Tunisie Medicale | Year: 2014

Background: Recently circadian clock genes have been identified in humans but information regarding their expression has remained very limited. The evaluation of circadian variations in the expression of clock genes in humans seems to be a major importance both from a fundamental point of view as a diagnostic and therapeutic perspective. In this context, several works including ours have described the fluctuation of clock genes. Aims: describing rhythmic expression of clock genes in intensive care units patients during 24h and we tried to determine the effect of the absence of synchronizers such as light?dark cycle on these rhythms. Methods: 15 patients received care in private room in intensive care units in the hospital Sahloul (5 comatous and 10 non comatous patients). For RNA isolation we used peripheral blood mononuclear cells which represent an ideal material to investigate non-invasively the human clock at the molecular level. Results: In the present study, we noticed that clock genes mRNA exhibit a circadian expression in comatose patients, while the rhythmicity of some studied genes disappeared in non-comatose patients. Conclusion: The disturbance of the rhythmic fluctuation of the clock genes could be the result of the effect of surgery on some biological rhythms as it could be explained by the lack of synchronizers in intensive care units such as light/dark cycle. © 2014, Maison du Medicine. All rights reserved. Source

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