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Fegas R.,Mohammed V University | Fegas R.,Laboratoire Of La Police Scientifique | Bensalem A.,Mohammed V University | Bettache Z.,Mohammed V University | And 3 more authors.
Asian Journal of Chemistry | Year: 2010

Reversed-phase high-performance liquid chromatography method was developed for separation of quinine and its diastereoisomer quinidine. The best separation was performed on symmetry C18 (150 × 4.6 id, particle size 3.5 μ m. Acetonitrile-water-triethylamine-acetic acid 9:90:0.25:0.75 (v/v/v/v) was used as a mobile phase with flow rate 1 mL/min. pH was adjusted to 3.03 with orthophosphoric acid. UV detection was performed at 254 nm. The validation of the method performance characteristics was established to be adequate for intended use.The evaluation of number of parameters,such as selectivity, linearity was realized with validation manager logician VWR international GmbH, Germany. Source


Fegas R.,Mohammed V University | Fegas R.,Laboratoire Of La Police Scientifique | Fegas R.,CNRS Institute of Molecular Sciences of Marseilles | Bensalem A.,Mohammed V University | And 5 more authors.
Asian Journal of Chemistry | Year: 2010

Quinine carbamate-type chiral stationary phase has been used for the direct liquid chromatographic enantiomer separation of a wide range of chiral acids. In the present work, we demonstrate that this the chiral stationary phase can also be extended to chiral discrimination of amino acid derivative phthalylvalin using methanol containing different organic acids in mobile phases. The influence of mobile phase composition and enantioselectivity was systematically investigated to gain insight into the overall chiral recognition mechanism. Source


Fegas R.,Mohammed V University | Fegas R.,Laboratoire Of La Police Scientifique | Fegas R.,CNRS Institute of Molecular Sciences of Marseilles | Zerkout S.,Mohammed V University | And 3 more authors.
Asian Journal of Chemistry | Year: 2013

The quinine carbamate type chiral stationary phase used for direct enantiomer separation of amino acid was studied. The influence of mobile phase composition, methanol and different acids were systematically investigated to gain an insight into the overall chiral recognition mechanism. © 2013 Asian Journal of Chemistry. Source

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