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Jankowski F.,Laboratoire Of Chimie Therapeutique Ea1043 | Verones V.,Laboratoire Of Chimie Therapeutique Ea1043 | Flouquet N.,Laboratoire Of Chimie Therapeutique Ea1043 | Carato P.,Laboratoire Of Chimie Therapeutique Ea1043 | And 2 more authors.
Tetrahedron | Year: 2010

A general method has been developed for the synthesis of 1,3-disubstituted-imidazo[1,5-a]quinazolin-5-(4H)-ones. This process involves initial microwave-assisted quinazolinone formation between anthranilamide and various Boc- or acylamino acids, followed by intramolecular cyclodehydration under acidic conditions. In the case of 3-monosubstituted-imidazoquinazolinones, the procedure needs the formation of the formamide derivatives by deprotection and formylation of the Boc-intermediates. © 2009 Elsevier Ltd. All rights reserved.

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