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Villeneuve-la-Rivière, France

Liberge G.,University of Lille Nord de France | Liberge G.,Laboratoire Of Chimie Organique Physique | Lebrun S.,University of Lille Nord de France | Lebrun S.,Laboratoire Of Chimie Organique Physique | And 4 more authors.
Comptes Rendus Chimie | Year: 2011

A new synthetic approach for the elaboration of diversely functionalized α-methylene-γ-butyrolactones has been developed. The first step was the preliminary construction of the lactone ring system equipped with easily manageable functionalities. As the key step, the ultimate deprotonation/ methoxymethylation/β-elimination sequence allowed installation of the exocyclic olefinic moiety and then permitted chemical transformation of the above-mentioned functionalities to complete the synthesis of the title compounds. © 2011 Académie des sciences. Published by Elsevier Masson SAS. All rights reserved. Source


Lebrun S.,University of Lille Nord de France | Lebrun S.,Laboratoire Of Chimie Organique Physique | Couture A.,University of Lille Nord de France | Couture A.,CNRS Laboratory of Catalysis and Solid State Chemistry | And 4 more authors.
Synthesis | Year: 2011

A series of diversely substituted 2H-2-benzazepine-1,3-diones were efficiently prepared from the unsaturated precursors, N-acyl-o-vinylbenzamides, through a ring-closing metathesis reaction. The parent compounds were easily obtained from the appropriate o-vinylbenzoic acids. © 2011 Georg Thieme Verlag Stuttgart New York. Source


Ahn G.,University of Lille Nord de France | Ahn G.,Laboratoire Of Chimie Organique Physique | Lorion M.,University of Lille Nord de France | Lorion M.,Laboratoire Of Chimie Organique Physique | And 8 more authors.
Synthesis | Year: 2011

A variety of poly and diversely substituted isoindoli-nones fused with six-membered heterocyclic moieties has been readily assembled through a sequence involving metalation of N-chloroalkylated models, subsequent interception with appropriate electrophiles and ultimate intramolecular annulation reaction. © Georg Thieme Verlag Stuttgart · New York. Source


Liberge G.,University of Lille Nord de France | Liberge G.,Laboratoire Of Chimie Organique Physique | Lebrun S.,University of Lille Nord de France | Lebrun S.,Laboratoire Of Chimie Organique Physique | And 4 more authors.
Helvetica Chimica Acta | Year: 2011

A concise synthetic approach to functionalized α- methylidenebutanolactams has been developed. The synthetic strategy is based on the preliminary assembly of the lactam template equipped with appropriate functionalities. Subsequent installation of the methylidene by a metalation/alkylation/elimination sequence completed the elaboration of the racemic title compounds. Copyright © 2011 Verlag Helvetica Chimica Acta AG, Zürich, Switzerland. Source


Lebrun S.,University of Lille Nord de France | Lebrun S.,Laboratoire Of Chimie Organique Physique | Couture A.,University of Lille Nord de France | Couture A.,CNRS Laboratory of Catalysis and Solid State Chemistry | And 4 more authors.
Tetrahedron Letters | Year: 2011

A variety of diversely substituted isoindeno[1,2-c]isoquinolin-5,11-diones has been readily assembled through a sequence involving a Suzuki-Miyaura cross-coupling reaction with enol phosphates combined with a ring-closing metathesis (RCM) reaction. Intramolecular carbocationic annulation reaction and ultimate oxidation of a latent hydroxyl functionality completed the synthesis of the target titled compounds. © 2011 Elsevier Ltd. All rights reserved. Source

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