Laboratoire Of Chimie Organique

El Jadida, Morocco

Laboratoire Of Chimie Organique

El Jadida, Morocco
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Haffad H.,Laboratoire Of Chimie Organique | Lancar I.T.,Chouaïb Doukkali University | Bakasse M.,Chouaïb Doukkali University
Eau, l'Industrie, les Nuisances | Year: 2014

Filtration of wastewater on natural materials is a very interesting model for the simplicity of its implementation and its low operating cost as well as its performance in terms of removal efficiency. In this context we have developed a system of filtration stage, consisting of agricultural land of sea sand and a clayey matrix. The main physicochemical parameters studied have focused on pH, conductivity, suspended solids (TSS), chemical oxygen demand (COD), ions orthophosphate (PO4 3-), ammonium ions (NH4 +) and chloride ions (Cl-). The results obtained by this system of treatment indicate a reduction from 28 to 94 % for the physicochemical parameters studied.


Zarrouki B.,University of Lyon | Zarrouki B.,INSA Lyon | Zarrouki B.,French Institute of Health and Medical Research | Zarrouki B.,French National Institute for Agricultural Research | And 26 more authors.
International Journal of Obesity | Year: 2010

Objective: We previously reported that the flavonoid cirsimarin exerts in vitro a strong lipolytic activity on isolated adipocytes. This study was therefore designed to evaluate in vivo the effects of cirsimarin on white adipose tissue (WAT) accretion in mice.Methods:Male CD1 mice were injected daily with either vehicle (intraperitoneal (i.p.)) or cirsimarin (25 or 50 mg kg -1 per day, i.p.) for 18 days. Mice were killed and fat pads weighted. Epididymal fat pads were used for cellularity measurement. Effects of cirsimarin treatment on lipolysis and lipogenesis in WAT were assessed. Results: Mice treated with 25 or 50 mg kg-1 per day cirsimarin showed a decrease in retroperitoneal (29 and 37% respectively, P<0.005) and epididymal (25 and 28% respectively, P<0.005) fat pad weights compared with controls. This effect was restricted to intra-abdominal WAT as no difference was noticed for subcutaneous inguinal WAT. The decrease in intra-abdominal WAT accretion was due to a decrease in adipose cell diameter (5 and 8% for 25 and 50 mg kg -1 per day cirsimarin, respectively) resulting in a 14 and 35% decrease in adipose cell volume while no change was noticed in total adipocyte number. Direct injection of cirsimarin (50 mg kg-1) to rats did not trigger lipolysis. In contrast, cirsimarin showed in vivo as well as in vitro a strong antilipogenic activity, which may be the critical aspect of its effects on fat accretion in mice. The inhibitory concentration 50% of cirsimarin on lipogenic activity in isolated adipocytes was found to be 1.28±0.04 μM. Cirsimarin given orally reduced intra-abdominal fat accretion in mice. Conclusion: Cirsimarin exerts potent antilipogenic effect and decreases adipose tissue deposition in mice. Cirsimarin could therefore be a potential candidate for the treatment of obesity. © 2010 Macmillan Publishers Limited All rights reserved.


Lallemand B.,Laboratoire Of Chimie Bioanalytique | Chaix F.,Laboratoire Of Chimie Organique | Bury M.,Laboratoire Of Toxicologie | Bruyere C.,Laboratoire Of Toxicologie | And 9 more authors.
Journal of Medicinal Chemistry | Year: 2011

18-β-Glycyrrhetinic acid (GA; 1) and many of its derivatives are cytotoxic in cancer cells. The current study aims to characterize the anticancer effects of 17 novel 1 derivatives. On the basis of these studies, N-(2-{3-[3,5-bis(trifluoromethyl)phenyl]ureido}ethyl)-glycyrrhetinamide (6b) appeared to be the most potent compound, with IC 50in vitro growth inhibitory concentrations in single-digit micromolarity in a panel of 8 cancer cell lines. Compound 6b is cytostatic and displays similar efficiency in apoptosis-sensitive versus apoptosis-resistant cancer cell lines through, at least partly, the inhibition of the activity of a cluster of a dozen kinases that are implicated in cancer cell proliferation and in the control of the actin cytoskeleton organization. Compound 6b also inhibits the activity of the 3 proteolytic units of the proteasome. Compound 6b thus represents an interesting hit from which future compounds could be derived to improve chemotherapeutic regimens that aim to combat cancers associated with poor prognoses. © 2011 American Chemical Society.


Essaghouani A.L.,Mohammed V University | Elmsellem H.,University Mohammed Premier | Ellouz M.,Mohammed V University | El Hafi M.,Mohammed V University | And 6 more authors.
Der Pharma Chemica | Year: 2016

Adsorption of 1-Ethyl-4-phenyl-2,3-dihydro-1H-1,5-benzodiazepin-2-one (P1) on mild steel surface in 1 M HCl solution and its corrosion inhibition properties has been studied by a series of techniques, such as polarization, electrochemical impedance spectroscopy (EIS), weight loss and quantum chemical calculation methods. Potentiodynamic polarization measurements showed that 1,5-benzodiazepine derivative inhibitor is mixed type. The degree of surface coverage was determined by using weight loss measurements and it was found that adsorption process of studied inhibitor on mild steel surface obey Langmuir adsorption isotherm.


Essaghouani A.L.,Mohammed V University | Elmsellem H.,University Mohammed Premier | Boulhaoua M.,Mohammed V University | Ellouz M.,Mohammed V University | And 6 more authors.
Der Pharma Chemica | Year: 2016

1-Benzyl-4-phenyl-2, 3-dihydro-1H-1,5-benzodiazepin-2-one (P1) was described as novel potent corrosion inhibitor for mild steel in 1M HCl. The inhibitive characteristic of compound (P1) was studied in detail via gravimetric measurement, electrochemical impedance spectroscopy and potentiodynamic polarization. In addition, a quantum chemical study suggests that the 1-Benzyl-4-phenyl-2, 3-dihydro-1H-1,5-benzodiazepin-2-one (P1) ring involved in this inhibitor is structurally essential for the protection of metal surface.


Harit T.,Laboratoire Of Chimie Organique | Harit T.,University Mohammed Premier | Isaad J.,Moulay Ismaï University | Isaad J.,University Mohammed Premier | And 2 more authors.
Tetrahedron | Year: 2016

The synthesis of a new functionalized tetrapyrazolic macrocycle with two bidentate bipyrazolic subunits and a lipophilic moiety bearing a donor-group is described. The complexing properties of this macrocycle towards the alkali metal ions (Li+, Na+, K+, Cs+) were studied by liquid-liquid extraction, and they showed a good extraction ability for Li+ and Na+, and a remarkable selectivity for the lithium cation in competitive conditions. © 2016 Elsevier Ltd.


Salhi A.,Laboratoire Of Leau Et Of Lenvironnement | Aarfane A.,Laboratoire Of Leau Et Of Lenvironnement | Tahiri S.,Laboratoire Of Leau Et Of Lenvironnement | Khamliche L.,Laboratoire Of Chimie Organique | And 4 more authors.
Journal of Materials and Environmental Science | Year: 2014

In this work, the degradation of Orange Acid 7 (OA7) dye by heterogeneous photocatalysis using a non-stoichiometric hydroxyapatite doped with titanium was investigated. First, the developed catalyst was characterized by different analytical techniques such as XRD, FTIR and TGA-DTA. Its effectiveness in degrading OA7 dye was then studied in a batch reactor. The effect of several parameters such as concentration, pH and irradiation time on photodegradation efficiency was investigated. Obtained results show that composite material HAP-Titanium has a significant photocatalytic activity complete discoloration of dying solution can be achieved after 16 hours of irradiation. Results show that discoloration performance depends on the catalyst mass, its titanium content, the initial dye concentration and the presence of oxygen in medium. However, photodegradation is little affected by the variation of pH of treated solutions. Increasing the mass of the catalyst and its percentage of titanium improves considerably the efficiency and the speed of discoloration. The optimum mass of the catalyst HAP-Titanium (Ti 11%) is about 2 g per liter of solution. Obtained results also show that discoloration yield decreases by increasing the initial concentration of dye and that the presence of oxygen in medium improves further the phodegradation phenomenon.


Khalfallah A.,Laboratoire Of Chimie Organique | Khaddachi M.T.,Laboratoire Of Chimie Organique
South African Journal of Chemistry | Year: 2010

Reactions of 5-methylisoxazol-3-amine with diethyl ethoxymethylenemalonate derivatives are described. By this methodethyl2-methyl-7-oxo-7H-isoxazolo[2,3-a] pyrimidine-6-carboxylate derivatives were prepared and characterized.


Queneau Y.,CNRS Institute of Molecular and Supramolecular Chemistry and Biochemistry | Queneau Y.,Laboratoire Of Chimie Organique Et Bioorganique | Dumoulin F.,CNRS Institute of Molecular and Supramolecular Chemistry and Biochemistry | Dumoulin F.,Laboratoire Of Chimie Organique | And 12 more authors.
Biochimie | Year: 2011

In nature, interfacial molecular recognition and chirality are of fundamental significance for the construction of biological assemblies. Lipid monolayers at liquid interface can be used as biomimetic models for studying molecular interactions in such assemblies. In this article, we will focus on the use of Langmuir monolayers for studying self-organization and insertion properties of several neoglycolipids. Two types of glycolipids have been considered, one in the context of the analysis of glycoconjugates of biological relevance, and one dealing with the ability of some glycoprobes to insert into a monolayer in relation with their efficiency for serving as membrane imaging systems. 2009 Elsevier Masson SAS. All rights reserved.


Bouhlassa S.,Mohammed V University | Ammary B.,Mohammed V University | Pare S.,Mohammed V University | Pare S.,Laboratoire Of Chimie Organique | Safsaf N.,Mohammed V University
Hydrogeology Journal | Year: 2016

In arid regions, knowledge of the evaporation rate from the water table is essential for appropriate management of scarce resources and to prevent land degradation. Soil chloride profiles in the unsaturated zone of a bare soil in an arid area of south-eastern Morocco were used to assess the evaporation flux, using chloride inventories in conjunction with evaporative demand. Moisture fluxes were calculated from measured chloride concentrations on the basis of a steady-state flow model. The chloride profiles displayed large variations in concentrations and had (1) low chloride concentrations near the soil surface, (2) maximum chloride concentrations at depths of 11–14 cm beneath the soil surface, respectively in July and February, and (3) gradually decreasing chloride concentrations while depth increased below these peaks. Evaporative demands were found to be inversely proportional to the depth of evaporation fronts and proportional to evaporation fluxes. In addition, the evaporation along the profiles seems to be controlled by the soil composition and texture. The investigation of chloride profiles in February and July enabled the determination of a value for annual evaporation (∼30 mm), which is in good agreement with the value estimated by the Allison-Barnes type model (∼32 mm). © 2016 Springer-Verlag Berlin Heidelberg

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