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Rezazgui O.,Laboratoire Of Chimie Des Substances Naturelles Ea1069 | Boens B.,Laboratoire Of Chimie Des Substances Naturelles Ea1069 | Teste K.,Laboratoire Of Chimie Des Substances Naturelles Ea1069 | Vergnaud J.,Laboratoire Of Chimie Des Substances Naturelles Ea1069 | And 3 more authors.
Tetrahedron Letters | Year: 2011

This paper describes a one-pot procedure for acetamide synthesis directly from amines and pyrimidine ester, without any catalyst or coupling agents. The inexpensive and simple reaction conditions are the most important features of this amidation. This reaction was performed with various amines, showing that long range stabilizing interactions (H-bonding and π-stacking) are the driving force for chemoselectivity.


Lucas R.,Laboratoire Of Chimie Des Substances Naturelles Ea1069 | Teste K.,Laboratoire Of Chimie Des Substances Naturelles Ea1069 | Zerrouki R.,Laboratoire Of Chimie Des Substances Naturelles Ea1069 | Champavier Y.,University of Limoges | Guilloton M.,Laboratoire Of Chimie Des Substances Naturelles Ea1069
Carbohydrate Research | Year: 2010

Protection-deprotection steps, which are usually needed for regioselective alkylation of pyrimidine deoxynucleosides, can be avoided by choosing the appropriate solvent. The combined effects of low dielectric constant and possible sodium chelation by pyrimidine nucleosides may account for the unexpected regioselectivity observed in THF. © 2009 Elsevier Ltd. All rights reserved.


Vergnaud J.,Laboratoire Of Chimie Des Substances Naturelles Ea1069 | Faugeras P.-A.,Laboratoire Of Chimie Des Substances Naturelles Ea1069 | Chaleix V.,Laboratoire Of Chimie Des Substances Naturelles Ea1069 | Champavier Y.,University of Limoges | Zerrouki R.,Laboratoire Of Chimie Des Substances Naturelles Ea1069
Tetrahedron Letters | Year: 2011

We describe in this Letter the synthesis of an original thymine azido-heterotrimer generated by Click Chemistry. This trimer has been obtained from an azido-thymidine and a new chloroethyl-propargylated PNA monomer analogue, after two azidation/click-reaction cycles. Conformational preferences of a rotameric intermediate have also been studied. © 2011 Elsevier Ltd. All rights reserved.


Jauberty L.,Laboratoire Of Chimie Des Substances Naturelles Ea1069 | Jauberty L.,Pe at rL SAS | Gloaguen V.,Laboratoire Of Chimie Des Substances Naturelles Ea1069 | Astier C.,Laboratoire Of Chimie Des Substances Naturelles Ea1069 | And 8 more authors.
Radioprotection | Year: 2011

This paper shows that natural materials such as barks can successfully replace synthetic resins for industrial purposes. Evaluated in batch conditions, biosorption of uranium on suitably prepared Douglas fir barks took place in less than 10 min and appeared to be optimum at pH>4. The biosorption process of uranium (uranyl form UO2 2+) was characterized in the optimal physico-chemical conditions and could be mathematically modeled as a Langmuir isotherm. With a maximum uranium specific uptake qmaxvalue of 1.16 meq.g-1 (138 mgU.g-1) it was found that the sorption capability of Douglas fir barks was at least five times higher for uranium than for other heavy metals such as lead. Adsorption of uranium contained in water leached from a former uranium mine was then monitored over a one-month period in a laboratory-scale chromatography column. The fixation capacity remained fairly constant throughout the whole testing period. Water radioactivity decreased from 1500 mBq.L-1 (0.12 mgU.L-1) to <5 mBq.L-1(0.4 μ gU.L-1) at the column exit. This technology was successfully transferred and tested through a pilot project under industrial conditions with the support of AREVA NC. © 2011 EDP Sciences.


Boens B.,Laboratoire Of Chimie Des Substances Naturelles Ea1069 | Teste K.,Laboratoire Of Chimie Des Substances Naturelles Ea1069 | Hadj-Bouazza A.,University of Quebec at Trois - Rivieres | Ismaili J.,University of Quebec at Trois - Rivieres | Zerrouki R.,Laboratoire Of Chimie Des Substances Naturelles Ea1069
Nucleosides, Nucleotides and Nucleic Acids | Year: 2012

This work deals with the synthesis of a new nitrogen mustard derivative based on thymine. To introduce the bis(2-chloroethyl)amine group to position 4 of the pyrimidine base, many strategies were explored and the desired compound was finally obtained, thanks to a synthetic pathway in five steps. Copyright © Taylor and Francis Group, LLC.

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