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Bellete B.,Laboratoire Of Parasitologie Et Mycologie | Raberin H.,Laboratoire Of Parasitologie Et Mycologie | Flori P.,Laboratoire Of Parasitologie Et Mycologie | El Akssi S.,Laboratoire Aliments | And 4 more authors.
Natural Product Research | Year: 2012

The aim of the study was to determine the antifungal effects of the essential oil of Thymus broussonetii Boiss (EOT), an endemic plant in Morocco against Candida albicans, Aspergillus fumigatus and the dermatophytes. EOT was extracted by steam distillation. A suspension of up to 500μL of C. albicans at a concentration of 108CFUmL-1 and A. fumigatus at a concentration of 1010sporesmL-1 were inhibited by 20μL of EOT incorporated in tubes containing 4mL of Sabouraud broth. In Sabouraud-chloramphenicol agar slants containing different concentrations of essential oil, 5104 A. fumigatus spores were inhibited by 6L (0.0015mLmL-1) of the EOT. It has shown good anti-C. albicans and anti-A. fumigatus activity. All the dermatophytes tested were inhibited by 3L (0.00075mLmL1) of EOT; the latter has the potential to be a good alternative to the conventional antifungal drugs which are usually expensive and with high toxicity. © 2012 Copyright Taylor and Francis Group, LLC.

Krim J.,Goethe University Frankfurt | Sillahi B.,Laboratoire Of Chimie Bioorganique Et Macromoleculaire | Taourirte M.,Laboratoire Of Chimie Bioorganique Et Macromoleculaire | Eddarir S.,Laboratoire Of Chimie Bioorganique Et Macromoleculaire | Engels J.W.,Goethe University Frankfurt
Collection of Czechoslovak Chemical Communications | Year: 2011

The novel pyrimidine carboacyclonucleoside analogues containing propargylated aryl side chains were synthesized via palladium-catalyzed cross-coupling reactions as a key step. The synthesized compounds were screened for their antibacterial activity against four microorganisms: Staphylococcus aureus (CIP 53.154; Gram positive), Enterococcus hirae (CIP 58.55; Gram positive), Pseudomonas aeruginosa (CIP A22; Gram negative), Escherichia coli (CIP 54.8; Gram negative). Some of the prepared products showed promising antibacterial activity against the nosocomial E. hirae. © 2011 Institute of Organic Chemistry and Biochemistry.

El Mahdi H.,Laboratoire Of Chimie Bioorganique Et Macromoleculaire | Abkhar Z.,Laboratoire Of Chimie Bioorganique Et Macromoleculaire | Taourirte M.,Laboratoire Of Chimie Bioorganique Et Macromoleculaire
Journal of Materials and Environmental Science | Year: 2012

The condensation of aldoses with the compounds 1, 3-diones or b-diketones in the presence of a catalyst in an alcoholic medium, produced furan polyols with hydroxylated chains. The first synthesis of this class of compounds was accomplished by Garcia Gonzalez in the presence of ZnCl2 like catalyst. The yields of the reaction are about 32%. In this work, with CaCl2 as catalyst after the optimization of the reaction conditions, we obtained, starting from glucose, xylose and mannose a furan polyols with the yields superior to 90%. In the continuation of this work we exploited this reaction in the valorization of the vegetable matter through the transformation of hemicelluloses after hydrolysis into polyhydroxylated derivatives with furan cycles.

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